Schistosoma haematobium infection modulates Plasmodium falciparum parasite density and antimalarial antibody responses.
Parasite Immunol
; 42(4): e12702, 2020 04.
Article
en En
| MEDLINE
| ID: mdl-32020650
ABSTRACT
AIMS:
Schistosomiasis and malaria are endemic in sub-Saharan Africa where Schistosoma haematobium (Sh) and Plasmodium falciparum (Pf) coinfections are thus frequent. We explored the effect of Sh infection on antibody responses directed to Pf merozoite antigens and on malaria susceptibility in Beninese children. METHODS ANDRESULTS:
A total of 268 children were followed during a malaria transmission season. Detection of Pf infection was performed by microscopy and rapid diagnostic tests. Sh infection was determined in urine by microscopy. Antimalarial antibody, cytokine and HLA-G concentrations were quantified by ELISA. The expression of HLA-G receptors by immune cells was assessed by flow cytometry. Children infected by Sh had higher concentrations of IgG1 directed to MSP3 and GLURPR0 , IgG2 directed to GLURPR0 and IgG3 directed to MSP3, GLURPR0 and GLURPR2 and have lower Pf densities than those uninfected by Sh. No difference in cytokine and HLA-G concentrations was observed between Sh egg carriers and non-carriers.CONCLUSION:
Schistosoma haematobium modulates host immune responses directed to Pf antigens. The absence of immune downregulation usually observed during helminth infections is surprising in our study. We hypothesize that the stage of Sh development could partly explain the immune pathways leading to increased antibody levels that favour better control of Pf parasitemia.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
/
Schistosoma haematobium
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Esquistosomiasis Urinaria
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Anticuerpos Antiprotozoarios
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Malaria Falciparum
/
Antimaláricos
Límite:
Animals
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Child
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Child, preschool
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Female
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Humans
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Male
País/Región como asunto:
Africa
Idioma:
En
Revista:
Parasite Immunol
Año:
2020
Tipo del documento:
Article