Retrospective review of delayed adverse events secondary to treatment with a smooth, cohesive 20-mg/mL hyaluronic acid filler in 4500 patients.
J Am Acad Dermatol
; 83(1): 86-95, 2020 Jul.
Article
en En
| MEDLINE
| ID: mdl-32035107
ABSTRACT
BACKGROUND:
Recent publications have suggested an increased risk of delayed adverse events (DAEs) with a smooth, cohesive 20-mg/mL hyaluronic acid filler, Juvéderm Voluma (HA-V).OBJECTIVE:
To examine the occurrence of HA-V DAEs and identify patterns and characteristics.METHODS:
Charts from patients who received HA-V between February 1, 2009, and February 28, 2018 from 2 clinics were analyzed.RESULTS:
In 4500 patients who received 9324 treatments with HA-V, 44 DAEs were identified, for a combined incidence of 0.98% per patient, 0.47% per treatment, and 0.23% per syringe. Patients with DAEs received a slightly larger cumulative amount of HA-V than those who did not. Delayed swelling and nodule formation were the most common reactions and occurred a median of 4 months after treatment, with an increase in frequency between October and January. About a third were preceded by an identifiable immunologic stimulus. DAEs were transient and resolved without incident.LIMITATIONS:
The retrospective nature made it difficult to capture time to resolution or remember potential triggers.CONCLUSION:
In this large, long-term, retrospective review, HA-V DAEs occurred at a rate of 0.98% per patient. Although the exact cause has yet to be elucidated, we hypothesize that an increase in fragmentation during the HA-V degradation process may trigger an inflammatory response after an immunologic trigger.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Técnicas Cosméticas
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Dermatosis Facial
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Rellenos Dérmicos
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Ácido Hialurónico
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Am Acad Dermatol
Año:
2020
Tipo del documento:
Article