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Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development.
Jacques, Samuel; van der Sloot, Almer M; C Huard, Caroline; Coulombe-Huntington, Jasmin; Tsao, Sarah; Tollis, Sylvain; Bertomeu, Thierry; Culp, Elizabeth J; Pallant, Daniel; Cook, Michael A; Bonneil, Eric; Thibault, Pierre; Wright, Gerard D; Tyers, Mike.
Afiliación
  • Jacques S; Institute for Research in Immunology and Cancer, University of Montréal, Quebec H3T 1JH, Canada.
  • van der Sloot AM; Institute for Research in Immunology and Cancer, University of Montréal, Quebec H3T 1JH, Canada am.van.der.sloot@umontreal.ca md.tyers@umontreal.ca.
  • C Huard C; Institute for Research in Immunology and Cancer, University of Montréal, Quebec H3T 1JH, Canada.
  • Coulombe-Huntington J; Institute for Research in Immunology and Cancer, University of Montréal, Quebec H3T 1JH, Canada.
  • Tsao S; Institute for Research in Immunology and Cancer, University of Montréal, Quebec H3T 1JH, Canada.
  • Tollis S; Institute for Research in Immunology and Cancer, University of Montréal, Quebec H3T 1JH, Canada.
  • Bertomeu T; Institute for Research in Immunology and Cancer, University of Montréal, Quebec H3T 1JH, Canada.
  • Culp EJ; David Braley Center for Antibiotic Discovery, McMaster University, Hamilton, Ontario L8S 4L8, Canada.
  • Pallant D; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
  • Cook MA; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
  • Bonneil E; David Braley Center for Antibiotic Discovery, McMaster University, Hamilton, Ontario L8S 4L8, Canada.
  • Thibault P; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
  • Wright GD; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
  • Tyers M; David Braley Center for Antibiotic Discovery, McMaster University, Hamilton, Ontario L8S 4L8, Canada.
Genetics ; 214(4): 1103-1120, 2020 04.
Article en En | MEDLINE | ID: mdl-32094149
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Pirimidinas / Proteínas de Escherichia coli / Endopeptidasa Clp / Proteolisis / Imidazoles / Antibacterianos / Antineoplásicos Límite: Humans Idioma: En Revista: Genetics Año: 2020 Tipo del documento: Article País de afiliación: Canadá
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Pirimidinas / Proteínas de Escherichia coli / Endopeptidasa Clp / Proteolisis / Imidazoles / Antibacterianos / Antineoplásicos Límite: Humans Idioma: En Revista: Genetics Año: 2020 Tipo del documento: Article País de afiliación: Canadá