Mangiferin activates Nrf2 to attenuate cardiac fibrosis via redistributing glutaminolysis-derived glutamate.

Song, Junna; Meng, Yunxia; Wang, Meng; Li, Lanzhu; Liu, Zhao; Zheng, Kaiyan; Wu, Lanfang; Liu, Baolin; Hou, Fangjie; Li, Aiying

Song, Junna; Meng, Yunxia; Wang, Meng; Li, Lanzhu; Liu, Zhao; Zheng, Kaiyan; Wu, Lanfang; Liu, Baolin; Hou, Fangjie; Li, Aiying.

Afiliación

Song J; Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, Hebei University of Chinese Medicine, Shijiazhuang, 050200, Hebei, China.
Meng Y; Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang, 050200, Hebei, China.
Wang M; Center for Drug Innovation and Discovery, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, Hebei, China.
Li L; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, Jiangsu, China.
Liu Z; Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, Hebei University of Chinese Medicine, Shijiazhuang, 050200, Hebei, China.
Zheng K; Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, Hebei University of Chinese Medicine, Shijiazhuang, 050200, Hebei, China.
Wu L; Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, Hebei University of Chinese Medicine, Shijiazhuang, 050200, Hebei, China.
Liu B; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, Jiangsu, China.
Hou F; Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, Hebei University of Chinese Medicine, Shijiazhuang, 050200, Hebei, China. Electronic address: 15130687505@163.com.
Li A; Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang, 050200, Hebei, China. Electronic address: aiyingli1963@163.com.

Pharmacol Res ; 157: 104845, 2020 07.

Article en En | MEDLINE | ID: mdl-32353588

Asunto(s)

Cardiomiopatías/prevención & control; Ácido Glutámico/metabolismo; Glutatión/metabolismo; Miocardio/metabolismo; Miofibroblastos/efectos de los fármacos; Factor 2 Relacionado con NF-E2/agonistas; Xantonas/farmacología; Animales; Cardiomiopatías/genética; Cardiomiopatías/metabolismo; Cardiomiopatías/patología; Modelos Animales de Enfermedad; Fibrosis; Masculino; Ratones; Ratones Endogámicos C57BL; Miocardio/patología; Miofibroblastos/metabolismo; Miofibroblastos/patología; Factor 2 Relacionado con NF-E2/genética; Factor 2 Relacionado con NF-E2/metabolismo; Células 3T3 NIH; Ratas Sprague-Dawley; Transducción de Señal

Palabras clave

CB-839 (PubChem CID: 71577426); Cardiac fibrosis; Cycloheximide (PubChem CID: 6197); Dimethyl 2-oxoglutarate (PubChem CID: 25775); Glutaminolysis; L-Buthionine sulfoximine (PubChem CID: 119565); L-glutamic acid (PubChem CID: 33032); MG-132 (PubChem CID: 462382); ML385 (PubChem CID: 1383822); Mangiferin; Mangiferin (PubChem CID: 5281647); Nrf2

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácido Glutámico / Xantonas / Factor 2 Relacionado con NF-E2 / Miofibroblastos / Glutatión / Cardiomiopatías / Miocardio Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China

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