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Antimicrobial Susceptibility and Clonality of Vaginally Derived Multidrug-Resistant Mobiluncus Isolates in China.
Zhang, Xueying; Bai, Yongying; Zhang, Long; Draz, Mohamed S; Ruan, Zhi; Zhu, Yuning.
Afiliación
  • Zhang X; Department of Clinical Laboratory, Branch of National Clinical Research Center for Obstetrics and Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Bai Y; Department of Clinical Laboratory, Branch of National Clinical Research Center for Obstetrics and Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Zhang L; Department of Clinical Laboratory, Branch of National Clinical Research Center for Obstetrics and Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Draz MS; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
  • Ruan Z; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, USA.
  • Zhu Y; Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China r_z@zju.edu.cn zyn@zju.edu.cn.
Antimicrob Agents Chemother ; 64(8)2020 07 22.
Article en En | MEDLINE | ID: mdl-32513795
ABSTRACT
Here, the antimicrobial susceptibility, resistance mechanisms, and clonality of Mobiluncus sp. isolates recovered from gynecological outpatients in China were investigated. Compared to M. mulieris, M. curtisii exhibited higher antimicrobial resistance to metronidazole, clindamycin, and tetracycline. Whole-genome sequencing indicated that the clindamycin resistance gene erm(X) was located on a transposable element, Tn5432, which was composed of two IS1249 sequences. Phylogenetic analysis indicated that Mobiluncus spp. had high diversity, with isolates being grouped into several sporadic clades.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Clindamicina / Mobiluncus País/Región como asunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Año: 2020 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Clindamicina / Mobiluncus País/Región como asunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Año: 2020 Tipo del documento: Article País de afiliación: China