Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORÎ³t Inverse Agonist.

Cherney, Robert J; Cornelius, Lyndon A M; Srivastava, Anurag; Weigelt, Carolyn A; Marcoux, David; Duan, James J-W; Shi, Qing; Batt, Douglas G; Liu, Qingjie; Yip, Shiuhang; Wu, Dauh-Rurng; Ruzanov, Max; Sack, John; Khan, Javed; Wang, Jinhong; Yarde, Melissa; Cvijic, Mary Ellen; Mathur, Arvind; Li, Sha; Shuster, David; Khandelwal, Purnima; Borowski, Virna; Xie, Jenny; Obermeier, Mary; Fura, Aberra; Stefanski, Kevin; Cornelius, Georgia; Tino, Joseph A; Macor, John E; Salter-Cid, Luisa; Denton, Rex; Zhao, Qihong; Carter, Percy H; Dhar, T G Murali

Cherney, Robert J; Cornelius, Lyndon A M; Srivastava, Anurag; Weigelt, Carolyn A; Marcoux, David; Duan, James J-W; Shi, Qing; Batt, Douglas G; Liu, Qingjie; Yip, Shiuhang; Wu, Dauh-Rurng; Ruzanov, Max; Sack, John; Khan, Javed; Wang, Jinhong; Yarde, Melissa; Cvijic, Mary Ellen; Mathur, Arvind; Li, Sha; Shuster, David; Khandelwal, Purnima; Borowski, Virna; Xie, Jenny; Obermeier, Mary; Fura, Aberra; Stefanski, Kevin; Cornelius, Georgia; Tino, Joseph A; Macor, John E; Salter-Cid, Luisa; Denton, Rex; Zhao, Qihong; Carter, Percy H; Dhar, T G Murali.

Afiliación

Cherney RJ; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Cornelius LAM; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Srivastava A; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Weigelt CA; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Marcoux D; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Duan JJ; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Shi Q; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Batt DG; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Liu Q; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Yip S; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Wu DR; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Ruzanov M; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Sack J; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Khan J; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Wang J; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Yarde M; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Cvijic ME; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Mathur A; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Li S; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Shuster D; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Khandelwal P; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Borowski V; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Xie J; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Obermeier M; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Fura A; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Stefanski K; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Cornelius G; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Tino JA; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Macor JE; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Salter-Cid L; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Denton R; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Zhao Q; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Carter PH; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.
Dhar TGM; Bristol Myers Squibb Company, Research and Early Development, Princeton, New Jersey 08540-4000, United States.

ACS Med Chem Lett ; 11(6): 1221-1227, 2020 Jun 11.

Article en En | MEDLINE | ID: mdl-32551004

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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