Combinatorial Resurfacing of Dengue Envelope Protein Domain III Antigens Selectively Ablates Epitopes Associated with Serotype-Specific or Infection-Enhancing Antibody Responses.

Remmel, Jennifer L; Beauchemin, Kathryn S; Mishra, Akaash K; Frei, Julia C; Lai, Jonathan R; Bailey-Kellogg, Chris; Ackerman, Margaret E

Remmel, Jennifer L; Beauchemin, Kathryn S; Mishra, Akaash K; Frei, Julia C; Lai, Jonathan R; Bailey-Kellogg, Chris; Ackerman, Margaret E.

Afiliación

Remmel JL; Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, United States.
Beauchemin KS; Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire 03755, United States.
Mishra AK; Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire 03755, United States.
Frei JC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Bailey-Kellogg C; Department of Computer Science, Dartmouth College, Hanover, New Hampshire 03755, United States.
Ackerman ME; Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, United States.

ACS Comb Sci ; 22(9): 446-456, 2020 09 14.

Article en En | MEDLINE | ID: mdl-32574486

Asunto(s)

Anticuerpos Antivirales/química; Antígenos Virales/química; Virus del Dengue/química; Epítopos/química; Proteínas del Envoltorio Viral/química; Anticuerpos Antivirales/inmunología; Reacciones Antígeno-Anticuerpo; Antígenos Virales/inmunología; Virus del Dengue/inmunología; Epítopos/inmunología; Proteínas del Envoltorio Viral/inmunología

Palabras clave

directed evolution; epitope-focusing; immunogen design; protein resurfacing; saturation mutagenesis; yeast surface display

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas del Envoltorio Viral / Virus del Dengue / Anticuerpos Antivirales / Epítopos / Antígenos Virales Tipo de estudio: Risk_factors_studies Idioma: En Revista: ACS Comb Sci Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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