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ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.
Bas-Hoogendam, Janna Marie; Groenewold, Nynke A; Aghajani, Moji; Freitag, Gabrielle F; Harrewijn, Anita; Hilbert, Kevin; Jahanshad, Neda; Thomopoulos, Sophia I; Thompson, Paul M; Veltman, Dick J; Winkler, Anderson M; Lueken, Ulrike; Pine, Daniel S; van der Wee, Nic J A; Stein, Dan J.
Afiliación
  • Bas-Hoogendam JM; Department of Developmental and Educational Psychology, Leiden University, Institute of Psychology, Leiden, The Netherlands.
  • Groenewold NA; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
  • Aghajani M; Leiden Institute for Brain and Cognition, Leiden, The Netherlands.
  • Freitag GF; Department of Psychiatry & Mental Health, University of Cape Town, Cape Town, South Africa.
  • Harrewijn A; Department of Psychiatry, Amsterdam UMC / VUMC, Amsterdam, The Netherlands.
  • Hilbert K; Department of Research & Innovation, GGZ inGeest, Amsterdam, The Netherlands.
  • Jahanshad N; National Institute of Mental Health, Emotion and Development Branch, Bethesda, Maryland, USA.
  • Thomopoulos SI; National Institute of Mental Health, Emotion and Development Branch, Bethesda, Maryland, USA.
  • Thompson PM; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Veltman DJ; University of Southern California Keck School of Medicine, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Los Angeles, California, USA.
  • Winkler AM; University of Southern California Keck School of Medicine, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Los Angeles, California, USA.
  • Lueken U; University of Southern California Keck School of Medicine, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Los Angeles, California, USA.
  • Pine DS; Department of Psychiatry, Amsterdam UMC / VUMC, Amsterdam, The Netherlands.
  • van der Wee NJA; National Institute of Mental Health, Emotion and Development Branch, Bethesda, Maryland, USA.
  • Stein DJ; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Hum Brain Mapp ; 43(1): 83-112, 2022 01.
Article en En | MEDLINE | ID: mdl-32618421
ABSTRACT
Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA-Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. This paper elaborates on the concepts and methods informing the work of the working group to date, and describes the initial approach of the four subgroups studying generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobia. At present, the ENIGMA-Anxiety database contains information about more than 100 unique samples, from 16 countries and 59 institutes. Future directions include examining additional imaging modalities, integrating imaging and genetic data, and collaborating with other ENIGMA working groups. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMA-Anxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastornos de Ansiedad / Corteza Prefrontal / Neuroimagen / Sistema Límbico Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastornos de Ansiedad / Corteza Prefrontal / Neuroimagen / Sistema Límbico Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos