The barley lectin, horcolin, binds high-mannose glycans in a multivalent fashion, enabling high-affinity, specific inhibition of cellular HIV infection.

Jayaprakash, Nisha Grandhi; Singh, Amrita; Vivek, Rahul; Yadav, Shivender; Pathak, Sanmoy; Trivedi, Jay; Jayaraman, Narayanaswamy; Nandi, Dipankar; Mitra, Debashis; Surolia, Avadhesha

Jayaprakash, Nisha Grandhi; Singh, Amrita; Vivek, Rahul; Yadav, Shivender; Pathak, Sanmoy; Trivedi, Jay; Jayaraman, Narayanaswamy; Nandi, Dipankar; Mitra, Debashis; Surolia, Avadhesha.

Afiliación

Jayaprakash NG; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India.
Singh A; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India.
Vivek R; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India.
Yadav S; Department of Organic Chemistry, Indian Institute of Science, Bangalore, India.
Pathak S; Department of Biochemistry, Indian Institute of Science, Bangalore, India.
Trivedi J; National Centre for Cell Science, Pune University, Pune, India.
Jayaraman N; Department of Organic Chemistry, Indian Institute of Science, Bangalore, India.
Nandi D; Department of Biochemistry, Indian Institute of Science, Bangalore, India.
Mitra D; National Centre for Cell Science, Pune University, Pune, India.
Surolia A; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India. Electronic address: surolia@iisc.ac.in.

J Biol Chem ; 295(34): 12111-12129, 2020 08 21.

Article en En | MEDLINE | ID: mdl-32636304

Asunto(s)

Proteína gp120 de Envoltorio del VIH/química; Infecciones por VIH; VIH-1/química; Hordeum/química; Manosa/química; Lectinas de Plantas/química; Polisacáridos/química; Productos del Gen env del Virus de la Inmunodeficiencia Humana/química; Animales; Células HEK293; VIH-1/metabolismo; Hordeum/genética; Humanos; Masculino; Ratones; Lectinas de Plantas/genética; Conejos

Palabras clave

HIV gp120; anti-HIV agent; antiviral agent; glycoprotein; horcolin; isothermal titration calorimetry (ITC); lectin; molecular dynamics

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Polisacáridos / Hordeum / Proteína gp120 de Envoltorio del VIH / Infecciones por VIH / VIH-1 / Lectinas de Plantas / Productos del Gen env del Virus de la Inmunodeficiencia Humana / Manosa Límite: Animals / Humans / Male Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: India

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