Imidazo[1,2-<i>b</i>]pyrazole-7-Carboxamide Derivative Induces Differentiation-Coupled Apoptosis of Immature Myeloid Cells Such as Acute Myeloid Leukemia and Myeloid-Derived Suppressor Cells.

Kotogány, Edit; Balog, József Á; Nagy, Lajos I; Alföldi, Róbert; Bertagnolo, Valeria; Brugnoli, Federica; Demjén, András; Kovács, Anita K; Batár, Péter; Mezei, Gabriella; Szabó, Renáta; Kanizsai, Iván; Varga, Csaba; Puskás, László G; Szebeni, Gábor J

Imidazo[1,2-b]pyrazole-7-Carboxamide Derivative Induces Differentiation-Coupled Apoptosis of Immature Myeloid Cells Such as Acute Myeloid Leukemia and Myeloid-Derived Suppressor Cells.

Kotogány, Edit; Balog, József Á; Nagy, Lajos I; Alföldi, Róbert; Bertagnolo, Valeria; Brugnoli, Federica; Demjén, András; Kovács, Anita K; Batár, Péter; Mezei, Gabriella; Szabó, Renáta; Kanizsai, Iván; Varga, Csaba; Puskás, László G; Szebeni, Gábor J.

Afiliación

Kotogány E; Laboratory of Functional Genomics, Institute of Genetics, Biological Research Centre, Temesvári krt. 62, H6726 Szeged, Hungary.
Balog JÁ; PhD School in Biology, University of Szeged, H6726 Szeged, Hungary.
Nagy LI; Laboratory of Functional Genomics, Institute of Genetics, Biological Research Centre, Temesvári krt. 62, H6726 Szeged, Hungary.
Alföldi R; PhD School in Biology, University of Szeged, H6726 Szeged, Hungary.
Bertagnolo V; Avidin Ltd., Alsó kiköto sor 11/D, H6726 Szeged, Hungary.
Brugnoli F; PhD School in Biology, University of Szeged, H6726 Szeged, Hungary.
Demjén A; AstridBio Technologies Ltd., Wimmer Fülöp u. 1, H6728 Szeged Hungary.
Kovács AK; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44121 Ferrara, Italy.
Batár P; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44121 Ferrara, Italy.
Mezei G; Avidin Ltd., Alsó kiköto sor 11/D, H6726 Szeged, Hungary.
Szabó R; Avidin Ltd., Alsó kiköto sor 11/D, H6726 Szeged, Hungary.
Kanizsai I; Department of Hematology, Faculty of Medicine, University of Debrecen, Nagyerdei körút 98, H4032 Debrecen, Hungary.
Varga C; Department of Hematology, Faculty of Medicine, University of Debrecen, Nagyerdei körút 98, H4032 Debrecen, Hungary.
Puskás LG; Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, H6726 Szeged, Hungary.
Szebeni GJ; Avidin Ltd., Alsó kiköto sor 11/D, H6726 Szeged, Hungary.

Int J Mol Sci ; 21(14)2020 Jul 20.

Article en En | MEDLINE | ID: mdl-32698503

Asunto(s)

Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Leucemia Mieloide Aguda/tratamiento farmacológico; Células Supresoras de Origen Mieloide/efectos de los fármacos; Pirazoles/farmacología; Animales; Antineoplásicos/química; Diferenciación Celular/efectos de los fármacos; Femenino; Células HL-60; Humanos; Leucemia Mieloide Aguda/metabolismo; Masculino; Ratones Endogámicos BALB C; Persona de Mediana Edad; Células Supresoras de Origen Mieloide/citología; Células Supresoras de Origen Mieloide/metabolismo; Pirazoles/química; Células Tumorales Cultivadas; Adulto Joven

Palabras clave

acute myeloid leukemia; apoptosis; differentiation; myeloid-derived suppressor cells

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Leucemia Mieloide Aguda / Apoptosis / Células Supresoras de Origen Mieloide / Antineoplásicos Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Hungria

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