Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses.
Antiviral Res
; 182: 104874, 2020 10.
Article
en En
| MEDLINE
| ID: mdl-32735900
ABSTRACT
Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-ß (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Virus ARN
/
Replicación Viral
/
ADN-Topoisomerasas de Tipo I
/
Betacoronavirus
Límite:
Humans
Idioma:
En
Revista:
Antiviral Res
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos