MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas.

Oldrini, Barbara; Vaquero-Siguero, Nuria; Mu, Quanhua; Kroon, Paula; Zhang, Ying; Galán-Ganga, Marcos; Bao, Zhaoshi; Wang, Zheng; Liu, Hanjie; Sa, Jason K; Zhao, Junfei; Kim, Hoon; Rodriguez-Perales, Sandra; Nam, Do-Hyun; Verhaak, Roel G W; Rabadan, Raul; Jiang, Tao; Wang, Jiguang; Squatrito, Massimo

Oldrini, Barbara; Vaquero-Siguero, Nuria; Mu, Quanhua; Kroon, Paula; Zhang, Ying; Galán-Ganga, Marcos; Bao, Zhaoshi; Wang, Zheng; Liu, Hanjie; Sa, Jason K; Zhao, Junfei; Kim, Hoon; Rodriguez-Perales, Sandra; Nam, Do-Hyun; Verhaak, Roel G W; Rabadan, Raul; Jiang, Tao; Wang, Jiguang; Squatrito, Massimo.

Afiliación

Oldrini B; Seve Ballesteros Foundation Brain Tumor Group, Molecular Oncology Programme, Spanish National Cancer Research Center, CNIO, 28029, Madrid, Spain.
Vaquero-Siguero N; Seve Ballesteros Foundation Brain Tumor Group, Molecular Oncology Programme, Spanish National Cancer Research Center, CNIO, 28029, Madrid, Spain.
Mu Q; Division of Life Science, Department of Chemical and Biological Engineering, Center of Systems Biology and Human Health and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China.
Kroon P; Seve Ballesteros Foundation Brain Tumor Group, Molecular Oncology Programme, Spanish National Cancer Research Center, CNIO, 28029, Madrid, Spain.
Zhang Y; Beijing Neurosurgical Institute, Capital Medical University, 100050, Beijing, China.
Galán-Ganga M; Seve Ballesteros Foundation Brain Tumor Group, Molecular Oncology Programme, Spanish National Cancer Research Center, CNIO, 28029, Madrid, Spain.
Bao Z; Division of Life Science, Department of Chemical and Biological Engineering, Center of Systems Biology and Human Health and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China.
Wang Z; Beijing Neurosurgical Institute, Capital Medical University, 100050, Beijing, China.
Liu H; Beijing Neurosurgical Institute, Capital Medical University, 100050, Beijing, China.
Sa JK; Beijing Neurosurgical Institute, Capital Medical University, 100050, Beijing, China.
Zhao J; Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06531, Korea.
Kim H; Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Korea.
Rodriguez-Perales S; Department of Systems Biology, Columbia University, New York, NY, 10032, USA.
Nam DH; The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.
Verhaak RGW; Molecular Cytogenetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Center, CNIO, 28029, Madrid, Spain.
Rabadan R; Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06531, Korea.
Jiang T; The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.
Wang J; Department of Systems Biology, Columbia University, New York, NY, 10032, USA.
Squatrito M; Beijing Neurosurgical Institute, Capital Medical University, 100050, Beijing, China. taojiang1964@163.com.

Nat Commun ; 11(1): 3883, 2020 08 04.

Article en En | MEDLINE | ID: mdl-32753598

Asunto(s)

Neoplasias Encefálicas/tratamiento farmacológico; Metilasas de Modificación del ADN/genética; Enzimas Reparadoras del ADN/genética; Resistencia a Antineoplásicos/genética; Reordenamiento Génico; Glioma/tratamiento farmacológico; Recurrencia Local de Neoplasia/genética; Temozolomida/farmacología; Proteínas Supresoras de Tumor/genética; Adolescente; Adulto; Anciano; Animales; Neoplasias Encefálicas/genética; Línea Celular Tumoral; Aductos de ADN/efectos de los fármacos; Aductos de ADN/metabolismo; Metilación de ADN; Metilasas de Modificación del ADN/metabolismo; Enzimas Reparadoras del ADN/metabolismo; Femenino; Regulación Neoplásica de la Expresión Génica; Glioma/genética; Humanos; Masculino; Ratones; Persona de Mediana Edad; Recurrencia Local de Neoplasia/prevención & control; Regiones Promotoras Genéticas/genética; RNA-Seq; Temozolomida/uso terapéutico; Proteínas Supresoras de Tumor/metabolismo; Regulación hacia Arriba; Secuenciación Completa del Genoma; Ensayos Antitumor por Modelo de Xenoinjerto; Adulto Joven

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Metilasas de Modificación del ADN / Reordenamiento Génico / Resistencia a Antineoplásicos / Proteínas Supresoras de Tumor / Enzimas Reparadoras del ADN / Temozolomida / Glioma / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Screening_studies Límite: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: España

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