Genome-Scale Imaging of the 3D Organization and Transcriptional Activity of Chromatin.

Su, Jun-Han; Zheng, Pu; Kinrot, Seon S; Bintu, Bogdan; Zhuang, Xiaowei

Su, Jun-Han; Zheng, Pu; Kinrot, Seon S; Bintu, Bogdan; Zhuang, Xiaowei.

Afiliación

Su JH; Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, and Department of Physics, Harvard University, Cambridge, MA 02138, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Zheng P; Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, and Department of Physics, Harvard University, Cambridge, MA 02138, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Kinrot SS; Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, and Department of Physics, Harvard University, Cambridge, MA 02138, USA; Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA.
Bintu B; Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, and Department of Physics, Harvard University, Cambridge, MA 02138, USA. Electronic address: bbintu@g.harvard.edu.
Zhuang X; Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, and Department of Physics, Harvard University, Cambridge, MA 02138, USA. Electronic address: zhuang@chemistry.harvard.edu.

Cell ; 182(6): 1641-1659.e26, 2020 09 17.

Article en En | MEDLINE | ID: mdl-32822575

Asunto(s)

Núcleo Celular/metabolismo; Cromatina/metabolismo; Cromosomas Humanos/metabolismo; Ensayos Analíticos de Alto Rendimiento/métodos; Hibridación Fluorescente in Situ/métodos; Análisis de la Célula Individual/métodos; Algoritmos; Línea Celular; Núcleo Celular/genética; Cromatina/genética; Cromosomas Humanos/genética; ADN/genética; ADN/metabolismo; Genómica; Humanos; Procesamiento de Imagen Asistido por Computador; Conformación Molecular; Imagen Multimodal; Región Organizadora del Nucléolo/genética; Región Organizadora del Nucléolo/metabolismo; ARN/genética; ARN/metabolismo; Programas Informáticos

Palabras clave

3D genome organization; MERFISH; chromosome compartments; chromosome conformation; genome-scale imaging; multiplexed FISH; nuclear lamina; nuclear speckles; topologically associated domains; trans-chromosomal interaction

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cromatina / Núcleo Celular / Cromosomas Humanos / Hibridación Fluorescente in Situ / Ensayos Analíticos de Alto Rendimiento / Análisis de la Célula Individual Límite: Humans Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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