New lead discovery of insect growth regulators based on the scaffold hopping strategy.

Jiang, Biaobiao; Guo, Bingbo; Cui, Jialin; Dong, Yawen; Cui, Li; Zhang, Li; Yang, Qing; Yang, Xinling

Jiang, Biaobiao; Guo, Bingbo; Cui, Jialin; Dong, Yawen; Cui, Li; Zhang, Li; Yang, Qing; Yang, Xinling.

Afiliación

Jiang B; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Guo B; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Cui J; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Dong Y; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Cui L; Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Zhang L; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China. Electronic address: zhang_li@cau.edu.cn.
Yang Q; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Yang X; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China. Electronic address: yangxl@cau.edu.cn.

Bioorg Med Chem Lett ; 30(21): 127500, 2020 11 01.

Article en En | MEDLINE | ID: mdl-32822762

Asunto(s)

Amidas/farmacología; Descubrimiento de Drogas; Hormonas Juveniles/farmacología; Mariposas Nocturnas/efectos de los fármacos; Pirazoles/farmacología; Amidas/síntesis química; Amidas/química; Animales; Quitinasas/metabolismo; Relación Dosis-Respuesta a Droga; Hormonas Juveniles/síntesis química; Hormonas Juveniles/química; Simulación del Acoplamiento Molecular; Estructura Molecular; Pirazoles/síntesis química; Pirazoles/química; Receptores de Esteroides/metabolismo; Relación Estructura-Actividad

Palabras clave

Chitinase; Ecdysone receptor; Insect growth regulator; Molecular docking; Pyrazolamide; Scaffold hopping

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Descubrimiento de Drogas / Amidas / Hormonas Juveniles / Mariposas Nocturnas Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: China

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