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LOC389641 promotes papillary thyroid cancer progression by regulating the EMT pathway.
Chen, Cheng-Ze; Wen, Jia-Liang; Lin, Bang-Yi; Zheng, Chen; Quan, Rui-da; Zhang, Xiao-Hua; Qu, Jin-Miao.
Afiliación
  • Chen CZ; Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Wen JL; Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Lin BY; Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Zheng C; Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Quan RD; Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Zhang XH; Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Qu JM; Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
Biomark Med ; 14(11): 969-980, 2020 07.
Article en En | MEDLINE | ID: mdl-32940082
ABSTRACT

Aim:

Thyroid cancer (TC) is one of the most common types of endocrine malignancy and poses a significant challenge to human health. The long noncoding RNA 389641 (LOC389641) has been found to be associated with many types of cancer. However, the function of LOC389641 in papillary TC (PTC) remains unknown. Our aim is to explore LOC389641 expression and its role in TC. Materials &

methods:

The function of LOC389641 was determined by colony formation, migration and invasion assays in PTC. Western blot assays were performed to determine the biomarker of epithelial-mesenchymal transition.

Results:

In this study, we show that LOC389641 is involved in PTC, which suggests that it may be a target for TC therapies.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Progresión de la Enfermedad / Transición Epitelial-Mesenquimal / ARN Largo no Codificante / Cáncer Papilar Tiroideo Límite: Humans Idioma: En Revista: Biomark Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Progresión de la Enfermedad / Transición Epitelial-Mesenquimal / ARN Largo no Codificante / Cáncer Papilar Tiroideo Límite: Humans Idioma: En Revista: Biomark Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2020 Tipo del documento: Article