IP3-mediated Ca2+ release regulates atrial Ca2+ transients and pacemaker function by stimulation of adenylyl cyclases.

Capel, Rebecca A; Bose, Samuel J; Collins, Thomas P; Rajasundaram, Skanda; Ayagama, Thamali; Zaccolo, Manuela; Burton, Rebecca-Ann Beatrice; Terrar, Derek A

IP₃-mediated Ca²⁺ release regulates atrial Ca²⁺ transients and pacemaker function by stimulation of adenylyl cyclases.

Capel, Rebecca A; Bose, Samuel J; Collins, Thomas P; Rajasundaram, Skanda; Ayagama, Thamali; Zaccolo, Manuela; Burton, Rebecca-Ann Beatrice; Terrar, Derek A.

Afiliación

Capel RA; Department of Pharmacology, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, United Kingdom.
Bose SJ; Department of Pharmacology, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, United Kingdom.
Collins TP; Department of Pharmacology, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, United Kingdom.
Rajasundaram S; Department of Pharmacology, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, United Kingdom.
Ayagama T; Department of Pharmacology, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, United Kingdom.
Zaccolo M; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Burton RB; Department of Pharmacology, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, United Kingdom.
Terrar DA; Department of Pharmacology, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, United Kingdom.

Am J Physiol Heart Circ Physiol ; 320(1): H95-H107, 2021 01 01.

Article en En | MEDLINE | ID: mdl-33064562

Asunto(s)

Adenilil Ciclasas/metabolismo; Relojes Biológicos; Señalización del Calcio; Atrios Cardíacos/enzimología; Frecuencia Cardíaca; Receptores de Inositol 1,4,5-Trifosfato/metabolismo; Inositol 1,4,5-Trifosfato/metabolismo; Miocitos Cardíacos/enzimología; Nodo Sinoatrial/enzimología; Potenciales de Acción; Animales; Proteínas Quinasas Dependientes de AMP Cíclico/metabolismo; Cobayas; Atrios Cardíacos/citología; Isoenzimas; Masculino; Ratones; Retículo Sarcoplasmático/enzimología; Factores de Tiempo

Palabras clave

Ca2+ signaling; adenylyl cyclase; cardiac atria; cyclic AMP; inositol trisphosphate

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Nodo Sinoatrial / Relojes Biológicos / Inositol 1,4,5-Trifosfato / Adenilil Ciclasas / Señalización del Calcio / Miocitos Cardíacos / Receptores de Inositol 1,4,5-Trifosfato / Atrios Cardíacos / Frecuencia Cardíaca Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Am J Physiol Heart Circ Physiol Asunto de la revista: CARDIOLOGIA / FISIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido

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