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A mixture of chloromethylisothiazolinone and methylisothiazolinone impairs rat vascular smooth muscle by depleting thiols and thereby elevating cytosolic Zn2+ and generating reactive oxygen species.
Do, Van Quan; Seo, Yoon-Seok; Park, Jung-Min; Yu, Jieun; Duong, Men Thi Hoai; Nakai, Junichi; Kim, Sang-Kyum; Ahn, Hee-Chul; Lee, Moo-Yeol.
Afiliación
  • Do VQ; College of Pharmacy, Integrated Research Institute for Drug Development, and BK21 FOUR team, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326, Republic of Korea.
  • Seo YS; College of Pharmacy, Integrated Research Institute for Drug Development, and BK21 FOUR team, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326, Republic of Korea.
  • Park JM; College of Pharmacy, Integrated Research Institute for Drug Development, and BK21 FOUR team, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326, Republic of Korea.
  • Yu J; College of Pharmacy, Chungnam National University, Daejeon, 34134, Republic of Korea.
  • Duong MTH; College of Pharmacy, Integrated Research Institute for Drug Development, and BK21 FOUR team, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326, Republic of Korea.
  • Nakai J; Graduate School of Dentistry, Tohoku University, Miyagi, 980-8575, Japan.
  • Kim SK; College of Pharmacy, Chungnam National University, Daejeon, 34134, Republic of Korea.
  • Ahn HC; College of Pharmacy, Integrated Research Institute for Drug Development, and BK21 FOUR team, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326, Republic of Korea.
  • Lee MY; College of Pharmacy, Integrated Research Institute for Drug Development, and BK21 FOUR team, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326, Republic of Korea. mlee@dongguk.edu.
Arch Toxicol ; 95(2): 541-556, 2021 02.
Article en En | MEDLINE | ID: mdl-33074372
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Compuestos de Sulfhidrilo / Tiazoles / Zinc / Especies Reactivas de Oxígeno / Músculo Liso Vascular Tipo de estudio: Risk_factors_studies Límite: Animals / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Arch Toxicol Año: 2021 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Compuestos de Sulfhidrilo / Tiazoles / Zinc / Especies Reactivas de Oxígeno / Músculo Liso Vascular Tipo de estudio: Risk_factors_studies Límite: Animals / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Arch Toxicol Año: 2021 Tipo del documento: Article