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Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates.
Chowdari, Naidu S; Zhang, Yong; McDonald, Ivar; Johnson, Walter; Langley, David R; Sivaprakasam, Prasanna; Mate, Robert; Huynh, Tram; Kotapati, Srikanth; Deshpande, Madhura; Pan, Chin; Menezes, Daniel; Wang, Yichong; Rao, Chetana; Sarma, Ganapathy; Warrack, Bethanne M; Rangan, Vangipuram S; Mei-Chen, Sung; Cardarelli, Pina; Deshpande, Shrikant; Passmore, David; Rampulla, Richard; Mathur, Arvind; Borzilleri, Robert; Rajpal, Arvind; Vite, Gregory; Gangwar, Sanjeev.
Afiliación
  • Chowdari NS; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Zhang Y; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
  • McDonald I; Bristol Myers Squibb Research & Early Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
  • Johnson W; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Langley DR; Bristol Myers Squibb Research & Early Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
  • Sivaprakasam P; Bristol Myers Squibb Research & Early Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
  • Mate R; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Huynh T; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
  • Kotapati S; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Deshpande M; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Pan C; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Menezes D; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Wang Y; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Rao C; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Sarma G; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Warrack BM; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
  • Rangan VS; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Mei-Chen S; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Cardarelli P; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Deshpande S; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Passmore D; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Rampulla R; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
  • Mathur A; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
  • Borzilleri R; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
  • Rajpal A; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
  • Vite G; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
  • Gangwar S; Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States.
J Med Chem ; 63(22): 13913-13950, 2020 11 25.
Article en En | MEDLINE | ID: mdl-33155811
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Benzodiazepinas / Diseño de Fármacos / Inmunoconjugados / Tetrahidroisoquinolinas / Carcinoma Pulmonar de Células Pequeñas / Anticuerpos Monoclonales / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Benzodiazepinas / Diseño de Fármacos / Inmunoconjugados / Tetrahidroisoquinolinas / Carcinoma Pulmonar de Células Pequeñas / Anticuerpos Monoclonales / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos