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A variation in the infant oxytocin receptor gene modulates infant hippocampal volumes in association with sex and prenatal maternal anxiety.
Acosta, H; Tuulari, J J; Kantojärvi, K; Lewis, J D; Hashempour, N; Scheinin, N M; Lehtola, S J; Fonov, V S; Collins, D L; Evans, A; Parkkola, R; Lähdesmäki, T; Saunavaara, J; Merisaari, H; Karlsson, L; Paunio, T; Karlsson, H.
Afiliación
  • Acosta H; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, Finland; Department of Psychiatry and Psychotherapy, Philipps University of Marburg, Germany. Electronic address: hschas@utu.fi.
  • Tuulari JJ; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, Finland; Department of Psychiatry, University of Turku and Turku University Hospital, Turku, Finland; Turku Collegium for Science and Medicine, University of Turku, Finland; Departm
  • Kantojärvi K; Finnish Institute for Health and Welfare, Genomics and Biobank Unit, Helsinki, Finland; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
  • Lewis JD; Montreal Neurological Institute, McGill University, Montreal, Canada.
  • Hashempour N; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, Finland.
  • Scheinin NM; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, Finland; Department of Psychiatry, University of Turku and Turku University Hospital, Turku, Finland.
  • Lehtola SJ; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, Finland.
  • Fonov VS; Montreal Neurological Institute, McGill University, Montreal, Canada.
  • Collins DL; Montreal Neurological Institute, McGill University, Montreal, Canada.
  • Evans A; Montreal Neurological Institute, McGill University, Montreal, Canada.
  • Parkkola R; Department of Radiology, University of Turku and Turku University Hospital, Turku, Finland.
  • Lähdesmäki T; Department of Pediatric Neurology, University of Turku and Turku University Hospital, Turku, Finland.
  • Saunavaara J; Department of Medical Physics, Turku University Hospital, Turku, Finland.
  • Merisaari H; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, Finland; Department of Future Technologies, University of Turku, Turku, Finland; Center of Computational Imaging and Personalized Diagnostics, Case Western Reserve University, OH, U
  • Karlsson L; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Finland.
  • Paunio T; Finnish Institute for Health and Welfare, Genomics and Biobank Unit, Helsinki, Finland; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
  • Karlsson H; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, Finland; Department of Psychiatry, University of Turku and Turku University Hospital, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University
Psychiatry Res Neuroimaging ; 307: 111207, 2021 01 30.
Article en En | MEDLINE | ID: mdl-33168330
Genetic variants in the oxytocin receptor (OTR) have been linked to distinct social phenotypes, psychiatric disorders and brain volume alterations in adults. However, to date, it is unknown how OTR genotype shapes prenatal brain development and whether it interacts with maternal prenatal environmental risk factors on infant brain volumes. In 105 Finnish mother-infant dyads (44 female, 11-54 days old), the association of offspring OTR genotype rs53576 and its interaction with prenatal maternal anxiety (revised Symptom Checklist 90, gestational weeks 14, 24, 34) on infant bilateral amygdalar, hippocampal and caudate volumes were probed. A sex-specific main effect of rs53576 on infant left hippocampal volumes was observed. In boys compared to girls, left hippocampal volumes were significantly larger in GG-homozygotes compared to A-allele carriers. Furthermore, genotype rs53576 and prenatal maternal anxiety significantly interacted on right hippocampal volumes irrespective of sex. Higher maternal anxiety was associated both with larger hippocampal volumes in A-allele carriers than GG-homozygotes, and, though statistically weak, also with smaller right caudate volumes in GG-homozygotes than A-allele carriers. Our study results suggest that OTR genotype enhances hippocampal neurogenesis in male GG-homozygotes. Further, prenatal maternal anxiety might induce brain alterations that render GG-homozygotes compared to A-allele carriers more vulnerable to depression.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxitocina / Receptores de Oxitocina Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Infant / Male / Pregnancy Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2021 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxitocina / Receptores de Oxitocina Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Infant / Male / Pregnancy Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2021 Tipo del documento: Article