Metformin protects high glucose­cultured cardiomyocytes from oxidative stress by promoting NDUFA13 expression and mitochondrial biogenesis via the AMPK signaling pathway.

Liu, Xiang-Dong; Li, Yong-Guang; Wang, Guang-Yu; Bi, Ya-Guang; Zhao, Yu; Yan, Mei-Ling; Liu, Xuebo; Wei, Meng; Wan, Li-Li; Zhang, Qing-Yong

Metformin protects high glucosecultured cardiomyocytes from oxidative stress by promoting NDUFA13 expression and mitochondrial biogenesis via the AMPK signaling pathway.

Liu, Xiang-Dong; Li, Yong-Guang; Wang, Guang-Yu; Bi, Ya-Guang; Zhao, Yu; Yan, Mei-Ling; Liu, Xuebo; Wei, Meng; Wan, Li-Li; Zhang, Qing-Yong.

Afiliación

Liu XD; Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, P.R. China.
Li YG; Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.
Wang GY; Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.
Bi YG; Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.
Zhao Y; Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.
Yan ML; Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.
Liu X; Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, P.R. China.
Wei M; Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.
Wan LL; Division of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.
Zhang QY; Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China.

Mol Med Rep ; 22(6): 5262-5270, 2020 Dec.

Article en En | MEDLINE | ID: mdl-33174032

Asunto(s)

Complejo I de Transporte de Electrón/metabolismo; Metformina/farmacología; Chaperonas Moleculares/metabolismo; Miocitos Cardíacos/metabolismo; Proteínas Quinasas Activadas por AMP/metabolismo; Animales; Línea Celular; Supervivencia Celular/efectos de los fármacos; China; Complejo I de Transporte de Electrón/efectos de los fármacos; Glucosa/metabolismo; Hiperglucemia/metabolismo; Metformina/metabolismo; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Proteínas Mitocondriales/metabolismo; Chaperonas Moleculares/efectos de los fármacos; Miocitos Cardíacos/efectos de los fármacos; Biogénesis de Organelos; Estrés Oxidativo/efectos de los fármacos; Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma/metabolismo; Proteínas Serina-Treonina Quinasas; Ratas; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/efectos de los fármacos; Superóxido Dismutasa/metabolismo; Factores de Transcripción/genética

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Chaperonas Moleculares / Miocitos Cardíacos / Complejo I de Transporte de Electrón / Metformina Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Mol Med Rep Año: 2020 Tipo del documento: Article

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