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Characterization of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump in Klebsiella pneumoniae and Klebsiella quasipneumoniae from Patients in China.
He, Ruowen; Yang, Yongqiang; Wu, Yiping; Zhong, Lan-Lan; Yang, Yanxian; Chen, Guanping; Qin, Mingyang; Liang, Xiaoxue; Ahmed, Mohamed Abd El-Gawad El-Sayed; Lin, Minmin; Yan, Bin; Xia, Yong; Dai, Min; Chen, Hongtao; Tian, Guo-Bao.
Afiliación
  • He R; Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
  • Yang Y; Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China.
  • Wu Y; Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
  • Zhong LL; Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China.
  • Yang Y; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, China.
  • Chen G; Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
  • Qin M; Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China.
  • Liang X; Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
  • Ahmed MAEE; Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China.
  • Lin M; Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
  • Yan B; Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China.
  • Xia Y; Sun Yat-sen University School of Medicine, Guangzhou, China.
  • Dai M; Basic Medical College, Xinxiang Medical University, Xinxiang, China.
  • Chen H; School of Laboratory Medicine, Chengdu Medical College, Chengdu, China.
  • Tian GB; Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Antimicrob Agents Chemother ; 65(2)2021 01 20.
Article en En | MEDLINE | ID: mdl-33199390
ABSTRACT
Two multidrug-resistant (MDR) mcr-1-harboring Klebsiella pneumoniae isolates from patients with urinary tract infections and one MDR Klebsiella quasipneumoniae isolate from a patient with bloodstream infection were identified to carry tmexCD1-toprJ1 The addition of the efflux pump inhibitor reduced the tigecycline MIC against all three isolates by 8- to 16-fold. pKQBSI104-1 was transferred from K. quasipneumoniae to Escherichia coli J53 via conjugation. The tmexCD1-toprJ1-carrying plasmids pKP15ZE495-1 (102,569 bp) and pKQBSI104-1 (121,996 bp) were completely sequenced and analyzed.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por Klebsiella / Klebsiella pneumoniae Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por Klebsiella / Klebsiella pneumoniae Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Año: 2021 Tipo del documento: Article País de afiliación: China