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Clinical efficacy of Danhong injection in preventing contrast-induced acute kidney injury based on propensity score matching method. / 基于倾向性匹配法评价丹红注射液预防造影剂诱导的急性肾损伤的临床效果.
Wang, Jianglin; Zhou, Lingyun; Yin, Wenjun; Li, Daiyang; Hu, Can; Zuo, Xiaocong.
Afiliación
  • Wang J; Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha 410013. jianglin_wang@163.com.
  • Zhou L; Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha 410013.
  • Yin W; Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha 410013.
  • Li D; Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha 410013.
  • Hu C; Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha 410013.
  • Zuo X; Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha 410013. zuoxc08@126.com.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 45(10): 1193-1198, 2020 Oct 28.
Article en En, Zh | MEDLINE | ID: mdl-33268580
ABSTRACT

OBJECTIVES:

Contrast-induced acute kidney injury (CI-AKI) is the third cause of hospital-acquired AKI, and existing clinical prevention and treatment measures such as hydration therapy and/or administration of antioxidants N-acetylcysteine treatment and other treatments still show little effect on the prevention and treatment of CI-AKI. This study aims to explore the effect of Danhong injection on prevention of CI-AKI.

METHODS:

A total of 12 867 patients, who received coronary angiography, percutaneous coronary intervention, enhanced CT or vascular intervention in a tertiary hospital, were enrolled for this study. Among them, 423 in the treatment group received intravenous drip of Danhong injection, and 12 444 in the control group received routine medicine. Propensity score matching was conducted to balance confounding factors between the 2 groups and then the prevention effect of Danhong injection on CI-AKI was compared between them.

RESULTS:

A total of 423 pairs of patients were matched successfully. The incidence of CI-AKI in the non-Danhong control group was higher than that in the Danhong treatment group (5.7% vs 2.4%). The difference between the 2 groups was statistically significant (P<0.05). CI-AKI occurred maily in the Stage 1 in both the non-Danhong control group and the Danhong treatment group. The number of patients with Stage 1 of AKI in the control group was more than that in the treatment group, and the difference was statistically significant (P<0.05). The incidence of AKI in Stage 2 and Stage 3 was less in both groups, and the difference was not statistically significant (P>0.05).

CONCLUSIONS:

The results of this study support the use of Danhong injection in the prevention of the Stage 1 of CI-AKI.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lesión Renal Aguda / Intervención Coronaria Percutánea Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En / Zh Revista: Zhong Nan Da Xue Xue Bao Yi Xue Ban Asunto de la revista: MEDICINA Año: 2020 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lesión Renal Aguda / Intervención Coronaria Percutánea Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En / Zh Revista: Zhong Nan Da Xue Xue Bao Yi Xue Ban Asunto de la revista: MEDICINA Año: 2020 Tipo del documento: Article