Endothelial cell disruption drives increased blood-brain barrier permeability and cerebral edema in the Dahl SS/jr rat model of superimposed preeclampsia.

Maeda, Kenji J; McClung, Daniel M; Showmaker, Kurt C; Warrington, Junie P; Ryan, Michael J; Garrett, Michael R; Sasser, Jennifer M

Maeda, Kenji J; McClung, Daniel M; Showmaker, Kurt C; Warrington, Junie P; Ryan, Michael J; Garrett, Michael R; Sasser, Jennifer M.

Afiliación

Maeda KJ; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
McClung DM; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Showmaker KC; Department of Physiology, University of Mississippi Medical Center, Jackson, Mississippi.
Warrington JP; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Ryan MJ; Department of Data Science, University of Mississippi Medical Center, Jackson, Mississippi.
Garrett MR; Department of Neurology, University of Mississippi Medical Center, Jackson, Mississippi.
Sasser JM; Department of Physiology, University of Mississippi Medical Center, Jackson, Mississippi.

Am J Physiol Heart Circ Physiol ; 320(2): H535-H548, 2021 02 01.

Article en En | MEDLINE | ID: mdl-33275518

Asunto(s)

Barrera Hematoencefálica/metabolismo; Edema Encefálico/patología; Permeabilidad Capilar; Células Endoteliales/ultraestructura; Preeclampsia/patología; Animales; Membrana Basal/ultraestructura; Barrera Hematoencefálica/ultraestructura; Edema Encefálico/metabolismo; Vesículas Citoplasmáticas/ultraestructura; Células Endoteliales/metabolismo; Endotelio Vascular/metabolismo; Endotelio Vascular/ultraestructura; Femenino; Preeclampsia/metabolismo; Embarazo; Ratas; Ratas Endogámicas Dahl; Ratas Sprague-Dawley; Uniones Estrechas/ultraestructura

Palabras clave

autoregulation; cerebral blood flow; electron microscopy; fluorescent dextran; myogenic tone

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Preeclampsia / Edema Encefálico / Permeabilidad Capilar / Barrera Hematoencefálica / Células Endoteliales Tipo de estudio: Prognostic_studies Límite: Animals / Pregnancy Idioma: En Revista: Am J Physiol Heart Circ Physiol Asunto de la revista: CARDIOLOGIA / FISIOLOGIA Año: 2021 Tipo del documento: Article

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