Chronic active Epstein-Barr virus: a multidisciplinary approach.
BMJ Case Rep
; 13(12)2020 Dec 21.
Article
en En
| MEDLINE
| ID: mdl-33370940
ABSTRACT
A 17-year-old Caucasian male presented to ENT with angular stomatitis, oral ulceration and cervical lymphadenopathy. Over the subsequent 18 months he developed recurrent upper respiratory tract infections, pyrexia of unknown origin, oral ulceration and maxillary sinus osteomyelitis. Extensive investigation ensued from various specialties. Positive investigations included a mild but persistently elevated serum Epstein-Barr virus PCR; however, no unifying diagnosis was elicited. It is noteworthy that a significant factor contributing to a delay in his diagnosis was poor compliance with invasive investigations. Ultimately, deteriorating liver function prompted liver biopsy which confirmed a diagnosis of chronic active Epstein-Barr virus infection (CAEBV). This enabled referral for curative treatment in the form of a stem cell transplant. CAEBV is extremely rare in Western countries. Due to fatal complications early diagnosis is critical for successful treatment. Our case highlights the need for regular clinical re-evaluation and a comprehensive multispecialty approach in such cases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Grupo de Atención al Paciente
/
Herpesvirus Humano 4
/
Infecciones por Virus de Epstein-Barr
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Hígado
Tipo de estudio:
Screening_studies
Límite:
Adolescent
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Humans
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Male
Idioma:
En
Revista:
BMJ Case Rep
Año:
2020
Tipo del documento:
Article
País de afiliación:
Reino Unido