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Bicyclic Ligand-Biased Agonists of S1P1: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles.
Gilmore, John L; Xiao, Hai-Yun; Dhar, T G Murali; Yang, Michael; Xiao, Zili; Yang, Xiaoxia; Taylor, Tracy L; McIntyre, Kim W; Warrack, Bethanne M; Shi, Hong; Levesque, Paul C; Marino, Anthony M; Cornelius, Georgia; Mathur, Arvind; Shen, Ding Ren; Pang, Jian; Cvijic, Mary Ellen; Lehman-McKeeman, Lois D; Sun, Huadong; Xie, Jenny; Salter-Cid, Luisa; Carter, Percy H; Dyckman, Alaric J.
Afiliación
  • Gilmore JL; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Xiao HY; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Dhar TGM; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Yang M; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Xiao Z; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Yang X; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Taylor TL; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • McIntyre KW; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Warrack BM; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Shi H; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Levesque PC; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Marino AM; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Cornelius G; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Mathur A; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Shen DR; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Pang J; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Cvijic ME; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Lehman-McKeeman LD; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Sun H; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Xie J; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Salter-Cid L; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Carter PH; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
  • Dyckman AJ; Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
J Med Chem ; 64(3): 1454-1480, 2021 02 11.
Article en En | MEDLINE | ID: mdl-33492963
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Compuestos Bicíclicos con Puentes / Serina Endopeptidasas / Proproteína Convertasas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Compuestos Bicíclicos con Puentes / Serina Endopeptidasas / Proproteína Convertasas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos