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Clearance of heparan sulfate in the brain prevents neurodegeneration and neurocognitive impairment in MPS II mice.
Morimoto, Hideto; Kida, Sachiho; Yoden, Eiji; Kinoshita, Masafumi; Tanaka, Noboru; Yamamoto, Ryuji; Koshimura, Yuri; Takagi, Haruna; Takahashi, Kenichi; Hirato, Tohru; Minami, Kohtaro; Sonoda, Hiroyuki.
Afiliación
  • Morimoto H; Research Division, JCR Pharmaceuticals, 2-2-9 Murotani, Nishi-ku, Kobe 651-2241, Japan.
  • Kida S; Research Division, JCR Pharmaceuticals, 2-2-9 Murotani, Nishi-ku, Kobe 651-2241, Japan.
  • Yoden E; Research Division, JCR Pharmaceuticals, 2-2-9 Murotani, Nishi-ku, Kobe 651-2241, Japan.
  • Kinoshita M; Research Division, JCR Pharmaceuticals, 2-2-9 Murotani, Nishi-ku, Kobe 651-2241, Japan.
  • Tanaka N; Research Division, JCR Pharmaceuticals, 2-2-9 Murotani, Nishi-ku, Kobe 651-2241, Japan.
  • Yamamoto R; Research Division, JCR Pharmaceuticals, 2-2-9 Murotani, Nishi-ku, Kobe 651-2241, Japan.
  • Koshimura Y; Research Division, JCR Pharmaceuticals, 2-2-9 Murotani, Nishi-ku, Kobe 651-2241, Japan.
  • Takagi H; Research Division, JCR Pharmaceuticals, 2-2-9 Murotani, Nishi-ku, Kobe 651-2241, Japan.
  • Takahashi K; Research Division, JCR Pharmaceuticals, 2-2-9 Murotani, Nishi-ku, Kobe 651-2241, Japan.
  • Hirato T; Research Division, JCR Pharmaceuticals, 2-2-9 Murotani, Nishi-ku, Kobe 651-2241, Japan.
  • Minami K; Research Division, JCR Pharmaceuticals, 2-2-9 Murotani, Nishi-ku, Kobe 651-2241, Japan. Electronic address: minami-k@jcrpharm.co.jp.
  • Sonoda H; Research Division, JCR Pharmaceuticals, 2-2-9 Murotani, Nishi-ku, Kobe 651-2241, Japan. Electronic address: sonoda-h@jcrpharm.co.jp.
Mol Ther ; 29(5): 1853-1861, 2021 05 05.
Article en En | MEDLINE | ID: mdl-33508431
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Recombinantes de Fusión / Encéfalo / Proteínas Recombinantes / Mucopolisacaridosis II / Trastornos Neurocognitivos / Heparitina Sulfato Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2021 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Recombinantes de Fusión / Encéfalo / Proteínas Recombinantes / Mucopolisacaridosis II / Trastornos Neurocognitivos / Heparitina Sulfato Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2021 Tipo del documento: Article País de afiliación: Japón