Your browser doesn't support javascript.
loading
Age-Related Cognitive Changes as a Function of CAG Repeat in Child and Adolescent Carriers of Mutant Huntingtin.
Schultz, Jordan L; van der Plas, Ellen; Langbehn, Douglas R; Conrad, Amy L; Nopoulos, Peg C.
Afiliación
  • Schultz JL; Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
  • van der Plas E; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
  • Langbehn DR; Department of Pharmacy Practice and Sciences, University of Iowa College of Pharmacy, Iowa City, IA, USA.
  • Conrad AL; Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
  • Nopoulos PC; Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Ann Neurol ; 89(5): 1036-1040, 2021 05.
Article en En | MEDLINE | ID: mdl-33521985
Limited data exists regarding the disease course of Huntington's Disease (HD) in children and young adults. Here, we evaluate the trajectory of various cognitive skill development as a function of cytosine-adenine-guanine (CAG) repeat length in children and adolescents that carry the mutation that causes HD. We discovered that the development of verbal skills seems to plateau earlier as CAG repeat length increases. These findings increase our understanding of the relationship between neurodegeneration and neurodevelopment and may have far-reaching implications for future gene-therapy treatment strategies. ANN NEUROL 2021;89:1036-1040.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Envejecimiento / Cognición / Repeticiones de Trinucleótidos / Proteína Huntingtina Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Ann Neurol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Envejecimiento / Cognición / Repeticiones de Trinucleótidos / Proteína Huntingtina Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Ann Neurol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos