Concomitant neurodegenerative pathologies contribute to the transition from mild cognitive impairment to dementia.
Alzheimers Dement
; 17(7): 1121-1133, 2021 07.
Article
en En
| MEDLINE
| ID: mdl-33663011
ABSTRACT
INTRODUCTION:
The aged brain frequently exhibits multiple pathologies, rather than a single hallmark pathology (pure pathology [PurP]), ranging from low/intermediate levels of additional pathology (LowP) to mixed severe pathology (mixed SevP). We investigated the frequency of PurP, LowP, and mixed SevP, and the impact of additional LowP on cognition.METHODS:
Data came from 670 cases from the Brains for Dementia research program. Cases were categorized into PurP, mixed SevP, or a main disease with additional LowP; 508 cases had a clinical dementia rating.RESULTS:
69.9% of cases had LowP, 22.7% had PurP, and 7.5% had mixed SevP. Additional LowP increased the likelihood of having mild dementia versus mild cognitive impairment (MCI) by almost 20-fold (odds ratio = 19.5).DISCUSSION:
Most aged individuals have multiple brain pathologies. The presence of one additional LowP can significantly worsen cognitive decline, increasing the risk of transitioning from MCI to dementia 20-fold. Multimorbidity should be considered in dementia research and clinical studies.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Autopsia
/
Encéfalo
/
Demencia
/
Disfunción Cognitiva
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Multimorbilidad
Límite:
Aged80
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Alzheimers Dement
Año:
2021
Tipo del documento:
Article
País de afiliación:
Reino Unido