Copper-Catalyzed Asymmetric Borylacylation of Styrene and Indene Derivatives.
J Org Chem
; 86(6): 4616-4624, 2021 Mar 19.
Article
en En
| MEDLINE
| ID: mdl-33689325
ABSTRACT
The enantioselective copper-catalyzed borylacylation of aryl olefins with acyl chlorides and bis-(pinacolato)diboron is reported. This three-component reaction involves an enantioselective syn-borylcupration of the aryl olefin, followed by a nucleophilic attack on the acyl chloride. This reaction proceeds with a 2 mol % catalyst loading and is generally completed within 30 min at room temperature. Because the boron moiety can be converted into versatile functional groups and the carbonyl group is a ubiquitous functional group, the resulting chiral ß-borylated ketones are versatile intermediates in organic synthesis.
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Año:
2021
Tipo del documento:
Article
País de afiliación:
China