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Airway Surface Liquid pH Regulation in Airway Epithelium Current Understandings and Gaps in Knowledge.
Zajac, Miroslaw; Dreano, Elise; Edwards, Aurelie; Planelles, Gabrielle; Sermet-Gaudelus, Isabelle.
Afiliación
  • Zajac M; Department of Physics and Biophysics, Institute of Biology, Warsaw University of Life Sciences, 02-776 Warsaw, Poland.
  • Dreano E; Institut Necker Enfants Malades, INSERM U1151, 75015 Paris, France.
  • Edwards A; Centre de Recherche des Cordeliers, Sorbonne Université, INSERM, Université de Paris, 75006 Paris, France.
  • Planelles G; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
  • Sermet-Gaudelus I; Centre de Recherche des Cordeliers, Sorbonne Université, INSERM, Université de Paris, 75006 Paris, France.
Int J Mol Sci ; 22(7)2021 Mar 25.
Article en En | MEDLINE | ID: mdl-33806154
ABSTRACT
Knowledge on the mechanisms of acid and base secretion in airways has progressed recently. The aim of this review is to summarize the known mechanisms of airway surface liquid (ASL) pH regulation and their implication in lung diseases. Normal ASL is slightly acidic relative to the interstitium, and defects in ASL pH regulation are associated with various respiratory diseases, such as cystic fibrosis. Basolateral bicarbonate (HCO3-) entry occurs via the electrogenic, coupled transport of sodium (Na+) and HCO3-, and, together with carbonic anhydrase enzymatic activity, provides HCO3- for apical secretion. The latter mainly involves CFTR, the apical chloride/bicarbonate exchanger pendrin and paracellular transport. Proton (H+) secretion into ASL is crucial to maintain its relative acidity compared to the blood. This is enabled by H+ apical secretion, mainly involving H+/K+ ATPase and vacuolar H+-ATPase that carry H+ against the electrochemical potential gradient. Paracellular HCO3- transport, the direction of which depends on the ASL pH value, acts as an ASL protective buffering mechanism. How the transepithelial transport of H+ and HCO3- is coordinated to tightly regulate ASL pH remains poorly understood, and should be the focus of new studies.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bicarbonatos / Anhidrasas Carbónicas / Mucosa Respiratoria / Epitelio Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Polonia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bicarbonatos / Anhidrasas Carbónicas / Mucosa Respiratoria / Epitelio Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Polonia