Expression of Interferons Lambda 3 and 4 Induces Identical Response in Human Liver Cell Lines Depending Exclusively on Canonical Signaling.

Lunova, Mariia; Kubovciak, Jan; Smolková, Barbora; Uzhytchak, Mariia; Michalova, Kyra; Dejneka, Alexandr; Strnad, Pavel; Lunov, Oleg; Jirsa, Milan

Lunova, Mariia; Kubovciak, Jan; Smolková, Barbora; Uzhytchak, Mariia; Michalova, Kyra; Dejneka, Alexandr; Strnad, Pavel; Lunov, Oleg; Jirsa, Milan.

Afiliación

Lunova M; Institute for Clinical & Experimental Medicine (IKEM), 14021 Prague, Czech Republic.
Kubovciak J; Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Smolková B; Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.
Uzhytchak M; Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.
Michalova K; Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine of Charles University, 12808 Prague, Czech Republic.
Dejneka A; Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.
Strnad P; Department of Internal Medicine III, University Hospital RWTH (Rheinisch-Westfälisch Technische Hochschule) Aachen, 52062 Aachen, Germany.
Lunov O; Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.
Jirsa M; Institute for Clinical & Experimental Medicine (IKEM), 14021 Prague, Czech Republic.

Int J Mol Sci ; 22(5)2021 Mar 04.

Article en En | MEDLINE | ID: mdl-33806448

Asunto(s)

Hepatocitos/inmunología; Hepatocitos/metabolismo; Interferones/genética; Interferones/metabolismo; Interleucinas/genética; Interleucinas/metabolismo; Línea Celular; Expresión Génica; Técnicas de Inactivación de Genes; Células Hep G2; Humanos; Factores Reguladores del Interferón/genética; Factores Reguladores del Interferón/metabolismo; Interferones/deficiencia; Subunidad beta del Receptor de Interleucina-10/deficiencia; Subunidad beta del Receptor de Interleucina-10/genética; Subunidad beta del Receptor de Interleucina-10/metabolismo; Interleucinas/deficiencia; ARN Mensajero/genética; ARN Mensajero/metabolismo; Receptores de Interferón/deficiencia; Receptores de Interferón/genética; Receptores de Interferón/metabolismo; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Transducción de Señal; Transfección

Palabras clave

IFNLR1; IL10R2; interferon stimulated genes; knockout; transcriptome

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Interleucinas / Interferones / Hepatocitos Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: República Checa

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