Serum insulin-like growth factor-1 concentrations in healthy cats before and after weight gain and weight loss.
J Vet Intern Med
; 35(3): 1274-1278, 2021 May.
Article
en En
| MEDLINE
| ID: mdl-33830548
ABSTRACT
BACKGROUND:
Measurement of serum concentrations of insulin-like growth factor (IGF)-1 is used to diagnose acromegaly in cats.HYPOTHESIS:
Changes of body weight do not affect serum concentrations of IGF-1 in cats. ANIMALS Ten healthy purpose-bred cats.METHODS:
Prospective study. In lean cats, food availability was stepwise increased during the first week and given ad libitum for a total of 40 weeks to increase their body weight. From week 41 to week 60, food access was limited to reach a weight loss of 1% to 2% each week. Measurement of IGF-1 was performed at week 0, 16, 40, and 60. Insulin-like growth factor-1 was measured by radioimmunoassay. Body weight and IGF-1 were compared among the 4 time points.RESULTS:
Body weight increased by 44% from week 0 (4.5 ± 0.4 kg) to week 40 (6.5 ± 1.2 kg) (P < .001) and decreased by 25% from week 40 to week 60 (4.9 ± 0.7 kg) (P < .001). Serum IGF-1 concentrations did not differ during the study period (week 0, 16, 40, 60 500 ± 188, 479 ± 247, 470 ± 184, 435 ± 154 ng/mL, respectively; P = .38). Correlations with body weight were not observed. CONCLUSIONS AND CLINICAL IMPORTANCE Insulin-like growth factor-1 might not be influenced by changes of body weight in healthy cats, possibly suggesting that the latter is unimportant when interpreting IGF-1 results in this species.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Acromegalia
/
Enfermedades de los Gatos
Tipo de estudio:
Observational_studies
Límite:
Animals
Idioma:
En
Revista:
J Vet Intern Med
Asunto de la revista:
MEDICINA INTERNA
/
MEDICINA VETERINARIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Suiza