Tissue calcification and alkaline phosphatase activity in uraemic rats.
Scand J Urol Nephrol
; 22(1): 45-51, 1988.
Article
en En
| MEDLINE
| ID: mdl-3387911
ABSTRACT
The activity and localization of alkaline phosphatase activity (AP) in aorta and heart, and the incidence of calcifications in aorta, heart and kidney as well as cardial fibrosis were studied in uraemic rats treated with 1,25-dihydroxycholecalciferol (1,25-DCHH) and Nifedipine. 1,25-DHCC treatment elevated the serum Ca x P product and aggravated the development of renal and aortic calcifications and cardial fibrosis. Nifedipine did not protect against calcifications, but decreased the incidence of cardial fibrosis. The activity of AP was increased in the thoracic aorta in uraemia independent of 1,25-DHCC or Nifedipine treatment or presence of calcification. No changes of the AP activity were found in the heart.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Uremia
/
Calcinosis
/
Fosfatasa Alcalina
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Scand J Urol Nephrol
Año:
1988
Tipo del documento:
Article
País de afiliación:
Suecia