Liquid-liquid phase separation of Tau by self and complex coacervation.

Najafi, Saeed; Lin, Yanxian; Longhini, Andrew P; Zhang, Xuemei; Delaney, Kris T; Kosik, Kenneth S; Fredrickson, Glenn H; Shea, Joan-Emma; Han, Songi

Najafi, Saeed; Lin, Yanxian; Longhini, Andrew P; Zhang, Xuemei; Delaney, Kris T; Kosik, Kenneth S; Fredrickson, Glenn H; Shea, Joan-Emma; Han, Songi.

Afiliación

Najafi S; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California, USA.
Lin Y; Materials Research Laboratory, University of California Santa Barbara, Santa Barbara, California, USA.
Longhini AP; Department of Biomolecular Science and Engineering, University of California Santa Barbara, Santa Barbara, California, USA.
Zhang X; Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA.
Delaney KT; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.
Kosik KS; Materials Research Laboratory, University of California Santa Barbara, Santa Barbara, California, USA.
Fredrickson GH; Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA.
Shea JE; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.
Han S; Materials Research Laboratory, University of California Santa Barbara, Santa Barbara, California, USA.

Protein Sci ; 30(7): 1393-1407, 2021 07.

Article en En | MEDLINE | ID: mdl-33955104

Asunto(s)

Simulación por Computador; Modelos Químicos; Agregado de Proteínas; Proteínas tau/química; Humanos

Palabras clave

LLPS; coacervation; neurodegenerative disease; protein aggregation; protein droplets; tauopathy

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Simulación por Computador / Proteínas tau / Agregado de Proteínas / Modelos Químicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Protein Sci Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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