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Administration in fed state but not controlled release in the colon increases oral bioavailability of DF030263, a promising drug candidate for chronic lymphocytic leukemia.
Lee, Jong Bong; Zang, Xiaowei; Zgair, Atheer; Ooi, Ting Qian; Foley, David W; Voronin, Gregory; Kagan, Leonid; Soukarieh, Fadi; Gao, Rui; Shao, Hao; Soh, Wan Tying; Kim, Tae Hwan; Kim, Min Gi; Yun, Hwi-Yeol; Wilson, Anthony J; Fischer, Peter M; Gershkovich, Pavel.
Afiliación
  • Lee JB; School of Pharmacy & Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.
  • Zang X; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
  • Zgair A; School of Pharmacy & Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK; College of Pharmacy, University of Anbar, Anbar, Iraq.
  • Ooi TQ; School of Pharmacy & Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.
  • Foley DW; School of Pharmacy & Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.
  • Voronin G; Comparative Medicine Resources, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
  • Kagan L; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
  • Soukarieh F; School of Pharmacy & Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.
  • Gao R; School of Pharmacy & Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.
  • Shao H; School of Pharmacy & Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK; Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Soh WT; School of Pharmacy & Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.
  • Kim TH; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
  • Kim MG; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
  • Yun HY; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
  • Wilson AJ; School of Pharmacy & Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.
  • Fischer PM; School of Pharmacy & Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.
  • Gershkovich P; School of Pharmacy & Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK. Electronic address: pavel.gershkovich@nottingham.ac.uk.
Eur J Pharm Biopharm ; 165: 106-112, 2021 Aug.
Article en En | MEDLINE | ID: mdl-33991611
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Linfocítica Crónica de Células B / Periodo Posprandial / Quinasa 9 Dependiente de la Ciclina / Inhibidores de Proteínas Quinasas / Absorción Intestinal Límite: Animals / Humans / Male Idioma: En Revista: Eur J Pharm Biopharm Asunto de la revista: FARMACIA / FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Linfocítica Crónica de Células B / Periodo Posprandial / Quinasa 9 Dependiente de la Ciclina / Inhibidores de Proteínas Quinasas / Absorción Intestinal Límite: Animals / Humans / Male Idioma: En Revista: Eur J Pharm Biopharm Asunto de la revista: FARMACIA / FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido