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The association of genetically determined serum glycine with cardiovascular risk in East Asians.
Chang, Xuling; Wang, Ling; Guan, Shou Ping; Kennedy, Brian K; Liu, Jianjun; Khor, Chiea-Chuen; Low, Adrian F; Chan, Mark Yan-Yee; Yuan, Jian-Min; Koh, Woon-Puay; Friedlander, Yechiel; Dorajoo, Rajkumar; Heng, Chew-Kiat.
Afiliación
  • Chang X; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore; Khoo Teck Puat, National University Children's Medical Institute, National University Health System, Singapore 119074, Singapore.
  • Wang L; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore.
  • Guan SP; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Kennedy BK; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Centre for Healthy Longevity, National University of Singapore, Nati
  • Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
  • Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
  • Low AF; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore; National University Heart Centre, National University Health System, Singapore, 119074, Singapore.
  • Chan MY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore; National University Heart Centre, National University Health System, Singapore, 119074, Singapore.
  • Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  • Koh WP; Health Systems and Services Research, Duke-NUS Medical School Singapore, Singapore 169857, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore.
  • Friedlander Y; School of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.
  • Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore; Health Systems and Services Research, Duke-NUS Medical School Singapore, Singapore 169857, Singapore. Electronic address: dorajoor@gis.a-star.edu.sg.
  • Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore; Khoo Teck Puat, National University Children's Medical Institute, National University Health System, Singapore 119074, Singapore. Electronic address: paehck@nus.edu.sg.
Nutr Metab Cardiovasc Dis ; 31(6): 1840-1844, 2021 06 07.
Article en En | MEDLINE | ID: mdl-33992511
ABSTRACT
BACKGROUND AND

AIMS:

Glycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians. METHODS AND

RESULTS:

We conducted a genome-wide association study (GWAS) in Singaporean Chinese participants and investigated if genetically determined serum glycine were associated with incident coronary artery disease (CAD) (711 cases and 1,246 controls), cardiovascular death (1,886 cases and 21,707 controls) and angiographic CAD severity (as determined by the Modified Gensini score, N = 1,138).

CONCLUSION:

Our study, a first in East Asians, suggest a protective role of glycine against CAD.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Carbamoil-Fosfato Sintasa (Amoniaco) / Polimorfismo de Nucleótido Simple / Glicina Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Nutr Metab Cardiovasc Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Año: 2021 Tipo del documento: Article País de afiliación: Singapur
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Carbamoil-Fosfato Sintasa (Amoniaco) / Polimorfismo de Nucleótido Simple / Glicina Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Nutr Metab Cardiovasc Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Año: 2021 Tipo del documento: Article País de afiliación: Singapur