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A 5-year clinicopathological study on microscopic colitis at a Malaysian tertiary hospital.
Abdul Hafidz, M I; Zulkifli, K K; Win, T T; Mat Zin, A A; Mustaffa, N.
Afiliación
  • Abdul Hafidz MI; Universiti Sains Malaysia, School of Medical Sciences, Department of Medicine, Kubang Kerian, Kelantan, Malaysia.
  • Zulkifli KK; Universiti Teknologi Mara, Faculty of Medicine, Sungai Buloh, Selangor, Malaysia.
  • Win TT; International Medical University, School of Medicine, Kuala Lumpur, Malaysia.
  • Mat Zin AA; Hospital Universiti Sains Malaysia, Department of Pathology, Kubang Kerian, Kelantan, Malaysia.
  • Mustaffa N; Universiti Sains Malaysia, School of Medical Sciences, Kubang Kerian, Kelantan, Malaysia. nazri.mustaffa@usm.my.
Med J Malaysia ; 76(3): 318-325, 2021 05.
Article en En | MEDLINE | ID: mdl-34031329
INTRODUCTION: Microscopic colitis (MC) is a well-recognised cause of chronic diarrhoea in Western countries. It is classically associated with normal endoscopic findings and a higher prevalence among patients with autoimmune disease. Local information regarding this disease remains scarce. We identified patients diagnosed with MC over a five-year period, and then proceeded to analyse the clinical characteristics of these cases. MATERIALS AND METHODS: A retrospective study was conducted by identifying all histologically confirmed colitis cases diagnosed at Hospital Universiti Sains Malaysia from January 2015 until December 2019. Clinicodemographic data was retrieved from case notes of patients. RESULTS: Of the 299 cases with histological colitis, 23 (7.7%) were initially identified as MC. Two cases had incomplete data, while two others were excluded as the diagnoses were revised to inflammatory bowel disease. An incidence of 14 MC cases/1000 case-year was obtained using the 21 MC cases seen within the five-year period. MC subtypes for the 19 analysed cases i.e., lymphocytic colitis and collagenous colitis accounted for 13 (68.4%) and 6 (31.6%) cases, respectively. Eleven patients (57.9%) were females (M:F ratio 1:1.5) with a median age of 51 years. Only nine (47.3%) presented with diarrhoea; one subject (5.4%) had an autoimmune condition (Hashimoto thyroiditis). Normal endoscopic findings were found in 89.5% of patients. CONCLUSION: Approximately half of the subjects in our study who had histologically confirmed MC did not present with diarrhoea. Adequate biopsy samples despite normal colonoscopy findings are important in order to not miss the diagnosis of MC.
Asunto(s)
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Colitis Microscópica / Colitis Linfocítica Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Middle aged Idioma: En Revista: Med J Malaysia Año: 2021 Tipo del documento: Article País de afiliación: Malasia
Buscar en Google
Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Colitis Microscópica / Colitis Linfocítica Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Middle aged Idioma: En Revista: Med J Malaysia Año: 2021 Tipo del documento: Article País de afiliación: Malasia