Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs.

Wang, Qingbo S; Kelley, David R; Ulirsch, Jacob; Kanai, Masahiro; Sadhuka, Shuvom; Cui, Ran; Albors, Carlos; Cheng, Nathan; Okada, Yukinori; Aguet, Francois; Ardlie, Kristin G; MacArthur, Daniel G; Finucane, Hilary K

Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs.

Wang, Qingbo S; Kelley, David R; Ulirsch, Jacob; Kanai, Masahiro; Sadhuka, Shuvom; Cui, Ran; Albors, Carlos; Cheng, Nathan; Okada, Yukinori; Aguet, Francois; Ardlie, Kristin G; MacArthur, Daniel G; Finucane, Hilary K.

Afiliación

Wang QS; Broad Institute of MIT and Harvard, Cambridge, MA, USA. qingbow@broadinstitute.org.
Kelley DR; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. qingbow@broadinstitute.org.
Ulirsch J; PhD program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA. qingbow@broadinstitute.org.
Kanai M; Calico Life Sciences, South San Francisco, CA, USA.
Sadhuka S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Cui R; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Albors C; PhD program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.
Cheng N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Okada Y; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Aguet F; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
Ardlie KG; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
MacArthur DG; Harvard College, Cambridge, MA, USA.
Finucane HK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Nat Commun ; 12(1): 3394, 2021 06 07.

Article en En | MEDLINE | ID: mdl-34099641

Asunto(s)

Mapeo Cromosómico/métodos; Biología Computacional/métodos; Sitios de Carácter Cuantitativo; Aprendizaje Automático Supervisado; Adulto; Estudios de Cohortes; Conjuntos de Datos como Asunto; Perfilación de la Expresión Génica; Humanos; Polimorfismo de Nucleótido Simple

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Mapeo Cromosómico / Biología Computacional / Sitios de Carácter Cuantitativo / Aprendizaje Automático Supervisado Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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