A Novel Orthotopic Implantation Technique for Osteosarcoma Produces Spontaneous Metastases and Illustrates Dose-Dependent Efficacy of B7-H3-CAR T Cells.

Talbot, Lindsay Jones; Chabot, Ashley; Funk, Amy; Nguyen, Phuong; Wagner, Jessica; Ross, Aaron; Tillman, Heather; Davidoff, Andrew; Gottschalk, Stephen; DeRenzo, Christopher

Talbot, Lindsay Jones; Chabot, Ashley; Funk, Amy; Nguyen, Phuong; Wagner, Jessica; Ross, Aaron; Tillman, Heather; Davidoff, Andrew; Gottschalk, Stephen; DeRenzo, Christopher.

Afiliación

Talbot LJ; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, United States.
Chabot A; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, United States.
Funk A; Department of Veterinary Medicine, St. Jude Children's Research Hospital, Memphis, TN, United States.
Nguyen P; Department of Bone Marrow Transplant and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, United States.
Wagner J; Department of Bone Marrow Transplant and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, United States.
Ross A; University of Tennessee Health Sciences School of Medicine, Memphis, TN, United States.
Tillman H; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, United States.
Davidoff A; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, United States.
Gottschalk S; Department of Bone Marrow Transplant and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, United States.
DeRenzo C; Department of Bone Marrow Transplant and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, United States.

Front Immunol ; 12: 691741, 2021.

Article en En | MEDLINE | ID: mdl-34211478

Asunto(s)

Antígenos B7/inmunología; Neoplasias Óseas/terapia; Inmunoterapia Adoptiva; Osteosarcoma/terapia; Receptores Quiméricos de Antígenos/inmunología; Animales; Neoplasias Óseas/patología; Línea Celular Tumoral; Femenino; Humanos; Neoplasias Pulmonares/secundario; Neoplasias Pulmonares/terapia; Ratones; Osteosarcoma/patología; Tibia/patología; Resultado del Tratamiento; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

B7-H3; CAR; T cell therapy; model; orthotopic; osteosarcoma

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Óseas / Osteosarcoma / Inmunoterapia Adoptiva / Antígenos B7 / Receptores Quiméricos de Antígenos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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