New dihydro-ß-agarofuran sesquiterpenoids from Tripterygium wilfordii and their anti-inflammatory activity.
Bioorg Chem
; 114: 105140, 2021 09.
Article
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| MEDLINE
| ID: mdl-34229200
ABSTRACT
Twenty seven dihydro-ß-agarofuran sesquiterpenoids, including fifteen new congeners, wilforsinines I-W (1-9, 12-13, 24-27), and twelve known compounds were isolated from the dried root of Tripterygium wilfordii. The structures of the new sesquiterpenoids, wilforsinines I-W, were elucidated by extensive spectroscopic data analysis. The anti-inflammatory activity of isolates 1-27 were evaluated by examining their inhibitory effects on nitric oxide (NO) production in LPS-induced RAW 264.7 macrophage cells. Among them, wilforsinine K (3) and angulatin M (16) exerted optimal inhibitory effects on the production of NO in LPS-induced RAW 264.7 cells. Moreover, Western blot results revealed that their anti-inflammatory activities were correlated with the suppression of the expression of nitric oxide synthase (iNOS) and down-regulation of the level of NF-κB p65 phosphorylation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
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Antiinflamatorios no Esteroideos
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Tripterygium
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Inflamación
Límite:
Animals
Idioma:
En
Revista:
Bioorg Chem
Año:
2021
Tipo del documento:
Article