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Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
Wu, Liangxing; Zhang, Colin; He, Chunhong; Qian, Dingquan; Lu, Liang; Sun, Yaping; Xu, Meizhong; Zhuo, Jincong; Liu, Phillip C C; Klabe, Ronald; Wynn, Richard; Covington, Maryanne; Gallagher, Karen; Leffet, Lynn; Bowman, Kevin; Diamond, Sharon; Koblish, Holly; Zhang, Yue; Soloviev, Maxim; Hollis, Gregory; Burn, Timothy C; Scherle, Peggy; Yeleswaram, Swamy; Huber, Reid; Yao, Wenqing.
Afiliación
  • Wu L; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Zhang C; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • He C; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Qian D; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Lu L; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Sun Y; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Xu M; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Zhuo J; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Liu PCC; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Klabe R; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Wynn R; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Covington M; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Gallagher K; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Leffet L; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Bowman K; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Diamond S; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Koblish H; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Zhang Y; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Soloviev M; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Hollis G; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Burn TC; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Scherle P; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Yeleswaram S; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Huber R; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
  • Yao W; Incyte Research Institute, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
J Med Chem ; 64(15): 10666-10679, 2021 08 12.
Article en En | MEDLINE | ID: mdl-34269576
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Pirroles / Morfolinas / Inhibidores de Proteínas Quinasas / Receptor Tipo 1 de Factor de Crecimiento de Fibroblastos / Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos / Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos / Descubrimiento de Drogas Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Pirroles / Morfolinas / Inhibidores de Proteínas Quinasas / Receptor Tipo 1 de Factor de Crecimiento de Fibroblastos / Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos / Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos / Descubrimiento de Drogas Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos