Comprehensive Genomic and Transcriptomic Analysis of Three Synchronous Primary Tumours and a Recurrence from a Head and Neck Cancer Patient.

Bresadola, Luisa; Weber, David; Ritzel, Christoph; Löwer, Martin; Bukur, Valesca; Akilli-Öztürk, Özlem; Becker, Julia; Mehanna, Hisham; Schrörs, Barbara; Vascotto, Fulvia; Sahin, Ugur; Kong, Anthony

Bresadola, Luisa; Weber, David; Ritzel, Christoph; Löwer, Martin; Bukur, Valesca; Akilli-Öztürk, Özlem; Becker, Julia; Mehanna, Hisham; Schrörs, Barbara; Vascotto, Fulvia; Sahin, Ugur; Kong, Anthony.

Afiliación

Bresadola L; TRON-Translational Oncology, University Medical Center, Johannes Gutenberg University Mainz, Freiligrathstraße 12, 55131 Mainz, Germany.
Weber D; TRON-Translational Oncology, University Medical Center, Johannes Gutenberg University Mainz, Freiligrathstraße 12, 55131 Mainz, Germany.
Ritzel C; University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
Löwer M; TRON-Translational Oncology, University Medical Center, Johannes Gutenberg University Mainz, Freiligrathstraße 12, 55131 Mainz, Germany.
Bukur V; TRON-Translational Oncology, University Medical Center, Johannes Gutenberg University Mainz, Freiligrathstraße 12, 55131 Mainz, Germany.
Akilli-Öztürk Ö; TRON-Translational Oncology, University Medical Center, Johannes Gutenberg University Mainz, Freiligrathstraße 12, 55131 Mainz, Germany.
Becker J; TRON-Translational Oncology, University Medical Center, Johannes Gutenberg University Mainz, Freiligrathstraße 12, 55131 Mainz, Germany.
Mehanna H; Institute of Head and Neck Studies (InHANSE), University of Birmingham, Vincent Drive, Birmingham B15 2TT, UK.
Schrörs B; TRON-Translational Oncology, University Medical Center, Johannes Gutenberg University Mainz, Freiligrathstraße 12, 55131 Mainz, Germany.
Vascotto F; TRON-Translational Oncology, University Medical Center, Johannes Gutenberg University Mainz, Freiligrathstraße 12, 55131 Mainz, Germany.
Sahin U; TRON-Translational Oncology, University Medical Center, Johannes Gutenberg University Mainz, Freiligrathstraße 12, 55131 Mainz, Germany.
Kong A; University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.

Int J Mol Sci ; 22(14)2021 Jul 15.

Article en En | MEDLINE | ID: mdl-34299215

Asunto(s)

Neoplasias de Cabeza y Cuello/genética; Mutación; Recurrencia Local de Neoplasia/genética; Neoplasias Primarias Múltiples/genética; Anciano; Consumo de Bebidas Alcohólicas/genética; Resultado Fatal; Perfilación de la Expresión Génica; Genómica; Neoplasias de Cabeza y Cuello/patología; Neoplasias de Cabeza y Cuello/terapia; Humanos; Masculino; Recurrencia Local de Neoplasia/patología; Recurrencia Local de Neoplasia/terapia; Estadificación de Neoplasias; Neoplasias Primarias Múltiples/patología; Neoplasias Primarias Múltiples/terapia; Fumadores/estadística & datos numéricos

Palabras clave

RNA sequencing (RNA-seq); germline variants; immune cell infiltration; recurrent head and neck squamous cell carcinoma (HNSCC); somatic single nucleotide variants; synchronous multiple primary malignancies; whole exome sequencing (WES)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de Cabeza y Cuello / Mutación / Recurrencia Local de Neoplasia / Neoplasias Primarias Múltiples Tipo de estudio: Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Alemania

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