Antiproliferative Efficacy of <i>N</i>-(3-chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine, DW-8, in Colon Cancer Cells Is Mediated by Intrinsic Apoptosis.

Neupane, Rabin; Malla, Saloni; Abou-Dahech, Mariam Sami; Balaji, Swapnaa; Kumari, Shikha; Waiker, Digambar Kumar; Moorthy, N S Hari Narayana; Trivedi, Piyush; Ashby, Charles R; Karthikeyan, Chandrabose; Tiwari, Amit K

Antiproliferative Efficacy of N-(3-chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine, DW-8, in Colon Cancer Cells Is Mediated by Intrinsic Apoptosis.

Neupane, Rabin; Malla, Saloni; Abou-Dahech, Mariam Sami; Balaji, Swapnaa; Kumari, Shikha; Waiker, Digambar Kumar; Moorthy, N S Hari Narayana; Trivedi, Piyush; Ashby, Charles R; Karthikeyan, Chandrabose; Tiwari, Amit K.

Afiliación

Neupane R; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Health Science Campus, 3000 Arlington Ave, Toledo, OH 43614, USA.
Malla S; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Health Science Campus, 3000 Arlington Ave, Toledo, OH 43614, USA.
Abou-Dahech MS; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Health Science Campus, 3000 Arlington Ave, Toledo, OH 43614, USA.
Balaji S; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Health Science Campus, 3000 Arlington Ave, Toledo, OH 43614, USA.
Kumari S; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Health Science Campus, 3000 Arlington Ave, Toledo, OH 43614, USA.
Waiker DK; School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal 462033, India.
Moorthy NSHN; Department of Pharmacy, Indira Gandhi National Tribal University, Lalpur, Amarkantak 484887, India.
Trivedi P; Center of Innovation and Translational Research, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune 411030, India.
Ashby CR; Department of Pharmaceutical Sciences, College of Pharmacy, St. John's University, Queens, NY 11439, USA.
Karthikeyan C; Department of Pharmacy, Indira Gandhi National Tribal University, Lalpur, Amarkantak 484887, India.
Tiwari AK; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Health Science Campus, 3000 Arlington Ave, Toledo, OH 43614, USA.

Molecules ; 26(15)2021 Jul 22.

Article en En | MEDLINE | ID: mdl-34361570

Asunto(s)

Apoptosis/efectos de los fármacos; Neoplasias del Colon; Puntos de Control de la Fase G2 del Ciclo Celular/efectos de los fármacos; Antineoplásicos/síntesis química; Antineoplásicos/química; Antineoplásicos/farmacología; Supervivencia Celular/efectos de los fármacos; Neoplasias del Colon/tratamiento farmacológico; Neoplasias del Colon/metabolismo; Neoplasias del Colon/patología; Células HCT116; Células HT29; Humanos

Palabras clave

4-anilino-quinazoline; anticancer compound; colorectal cancer; cytotoxicity; intrinsic apoptosis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apoptosis / Neoplasias del Colon / Puntos de Control de la Fase G2 del Ciclo Celular Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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