Recent insights into mechanisms preventing ectopic centromere formation.
Open Biol
; 11(9): 210189, 2021 09.
Article
en En
| MEDLINE
| ID: mdl-34493071
ABSTRACT
The centromere is a specialized chromosomal structure essential for chromosome segregation. Centromere dysfunction leads to chromosome segregation errors and genome instability. In most eukaryotes, centromere identity is specified epigenetically by CENP-A, a centromere-specific histone H3 variant. CENP-A replaces histone H3 in centromeres, and nucleates the assembly of the kinetochore complex. Mislocalization of CENP-A to non-centromeric regions causes ectopic assembly of CENP-A chromatin, which has a devastating impact on chromosome segregation and has been linked to a variety of human cancers. How non-centromeric regions are protected from CENP-A misincorporation in normal cells is largely unexplored. Here, we review the most recent advances on the mechanisms underlying the prevention of ectopic centromere formation, and discuss the implications in human disease.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cromatina
/
Histonas
/
Centrómero
/
Segregación Cromosómica
/
Inestabilidad Genómica
/
Proteína A Centromérica
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Open Biol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos