[Influence of molecular pathology on oncological surgery of liver and bile duct tumors]. / Einfluss der Molekularpathologie auf die onkologische Chirurgie von Leber- und Gallengangstumoren.
Chirurg
; 92(11): 1003-1010, 2021 Nov.
Article
en De
| MEDLINE
| ID: mdl-34519849
ABSTRACT
BACKGROUND:
Molecular pathology is increasingly being used to guide treatment in oncology. Approximately 25% of all hepatocellular carcinomas (HCC) and 50% of cholangiocarcinomas (CCA) present with known cancer-relevant mutations; however, the impact of the mutations on the treatment of these tumors is not yet sufficiently understood.PURPOSE:
To evaluate the current literature on molecular pathological advances in HCC/CCA and the potential impact on oncological surgery. MATERIAL ANDMETHODS:
A comprehensive search of the available literature on currently known molecular biomarkers in HCC/CCA was performed in PubMed and clinitrials.gov. Following review, the potential impact of these biomarkers on oncological surgery was analyzed and is discussed.CONCLUSION:
Molecular pathological investigations can be used to support the classification of tumors and to determine the dignity of HCC/CCA. Predictive molecular biomarkers are not yet established in routine diagnostics but can be used to individualize advanced oncological treatment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de los Conductos Biliares
/
Colangiocarcinoma
/
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
De
Revista:
Chirurg
Año:
2021
Tipo del documento:
Article