Interferon and c-ets-1 genes in the translocation (9;11)(p22;q23) in human acute monocytic leukemia.
Science
; 231(4735): 265-7, 1986 Jan 17.
Article
en En
| MEDLINE
| ID: mdl-3455787
ABSTRACT
Gene probes for interferons alpha and beta 1 and v-ets were hybridized to metaphase chromosomes from three patients with acute monocytic leukemia who had a chromosomal translocation, t(9;11)(p22;q23). The break in the short arm of chromosome 9 split the interferon genes, and the interferon-beta 1 gene was translocated to chromosome 11. The c-ets-1 gene was translocated from chromosome 11 to the short arm of chromosome 9 adjacent to the interferon genes. No DNA rearrangement was observed when these probes were hybridized to genomic DNA from leukemic cells of two of the patients. The results suggest that the juxtaposition of the interferon and c-ets-1 genes may be involved in the pathogenesis of human monocytic leukemia.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Translocación Genética
/
Proto-Oncogenes
/
Interferón Tipo I
/
Leucemia Monocítica Aguda
Límite:
Humans
Idioma:
En
Revista:
Science
Año:
1986
Tipo del documento:
Article