A Novel Long Noncoding RNA Finetunes the DNA Damage Response in Hepatocellular Carcinoma.
Cancer Res
; 81(19): 4899-4900, 2021 10 01.
Article
en En
| MEDLINE
| ID: mdl-34598999
ABSTRACT
The study by Unfried and colleagues reports the intriguing discovery of a novel long noncoding RNA (lncRNA) with a critical role in the regulation of DNA damage response in hepatocellular carcinoma. Providing an exhaustive and detailed characterization of the complex network interactions within the double-stranded breaks in the DNA, the authors demonstrated that NIHCOLE serves as a scaffold and facilitator of nonhomologous end-joining machinery. This study greatly contributes to the growing evidence supporting the key roles of ncRNAs in health and disease. Although larger studies are needed to understand the potential of lncRNAs to improve the clinical management of patients with cancer, this study demonstrates that high expression of NIHCOLE may be associated with an impaired response to DNA damage-based therapies, in part through its role in preventing cell death.See related article by Unfried et al., p. 4910.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Carcinoma Hepatocelular
/
ARN Largo no Codificante
/
Neoplasias Hepáticas
Límite:
Humans
Idioma:
En
Revista:
Cancer Res
Año:
2021
Tipo del documento:
Article