Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug.

Liang, Xinxin; Yan, Ziyan; Wang, Ping; Liu, Yuhao; Ao, Xingkun; Liu, Zheng; Wang, Duo; Liu, Xiaochang; Zhu, Maoxiang; Gao, Shanshan; Xie, Dafei; Zhou, Pingkun; Gu, Yongqing

Liang, Xinxin; Yan, Ziyan; Wang, Ping; Liu, Yuhao; Ao, Xingkun; Liu, Zheng; Wang, Duo; Liu, Xiaochang; Zhu, Maoxiang; Gao, Shanshan; Xie, Dafei; Zhou, Pingkun; Gu, Yongqing.

Afiliación

Liang X; Hengyang Medical College, University of South China, Hengyang 421001, China.
Yan Z; Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Wang P; Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Liu Y; Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Ao X; Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Liu Z; Hengyang Medical College, University of South China, Hengyang 421001, China.
Wang D; School of Public Health, University of South China, Hengyang 421001, China.
Liu X; Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Zhu M; Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Gao S; Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Xie D; Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Zhou P; Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Gu Y; Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China.

Int J Mol Sci ; 22(21)2021 Oct 20.

Article en En | MEDLINE | ID: mdl-34768749

Asunto(s)

Transición Epitelial-Mesenquimal/efectos de la radiación; MicroARNs/genética; Fibrosis Pulmonar/genética; Células A549; Células Epiteliales Alveolares/metabolismo; Animales; Línea Celular Tumoral; Transición Epitelial-Mesenquimal/genética; Humanos; Factores de Transcripción de Tipo Kruppel/genética; Factores de Transcripción de Tipo Kruppel/metabolismo; Pulmón/metabolismo; Pulmón/fisiología; Lesión Pulmonar/fisiopatología; Masculino; Ratones; Ratones Endogámicos C57BL; MicroARNs/metabolismo; Fibrosis Pulmonar/metabolismo; Síndrome de Fibrosis por Radiación/genética; Transducción de Señal/fisiología; Factores de Transcripción de la Familia Snail/genética; Factores de Transcripción de la Familia Snail/metabolismo; Factores de Transcripción/metabolismo

Palabras clave

EMT; MZF1; miR-541-5p; radiation-induced pulmonary fibrosis; slug

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fibrosis Pulmonar / MicroARNs / Transición Epitelial-Mesenquimal Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: China

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