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Defining genome-wide CRISPR-Cas genome-editing nuclease activity with GUIDE-seq.
Malinin, Nikolay L; Lee, GaHyun; Lazzarotto, Cicera R; Li, Yichao; Zheng, Zongli; Nguyen, Nhu T; Liebers, Matthew; Topkar, Ved V; Iafrate, A John; Le, Long P; Aryee, Martin J; Joung, J Keith; Tsai, Shengdar Q.
Afiliación
  • Malinin NL; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Lee G; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Lazzarotto CR; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Li Y; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Zheng Z; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
  • Nguyen NT; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.
  • Liebers M; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA.
  • Topkar VV; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.
  • Iafrate AJ; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.
  • Le LP; Biophysics Program, Stanford University, Stanford, CA, USA.
  • Aryee MJ; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.
  • Joung JK; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.
  • Tsai SQ; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.
Nat Protoc ; 16(12): 5592-5615, 2021 12.
Article en En | MEDLINE | ID: mdl-34773119
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Genoma Humano / Reacción en Cadena de la Polimerasa / ARN Guía de Kinetoplastida / Sistemas CRISPR-Cas / Edición Génica / Proteína 9 Asociada a CRISPR Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: Nat Protoc Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Genoma Humano / Reacción en Cadena de la Polimerasa / ARN Guía de Kinetoplastida / Sistemas CRISPR-Cas / Edición Génica / Proteína 9 Asociada a CRISPR Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: Nat Protoc Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos