Mouse Embryonic Fibroblasts Isolated From Nthl1 D227Y Knockin Mice Exhibit Defective DNA Repair and Increased Genome Instability.

Marsden, Carolyn G; Das, Lipsa; Nottoli, Timothy P; Kathe, Scott D; Doublié, Sylvie; Wallace, Susan S; Sweasy, Joann B

Marsden, Carolyn G; Das, Lipsa; Nottoli, Timothy P; Kathe, Scott D; Doublié, Sylvie; Wallace, Susan S; Sweasy, Joann B.

Afiliación

Marsden CG; Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, VT 05405, USA-0068.
Das L; Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, Tucson, AZ 85724-5024, USA.
Nottoli TP; Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Kathe SD; Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, VT 05405, USA-0068.
Doublié S; Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, VT 05405, USA-0068.
Wallace SS; Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, VT 05405, USA-0068.
Sweasy JB; Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, VT 05405, USA-0068; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510; Department of Cellular and Molecular Medicine, University

DNA Repair (Amst) ; 109: 103247, 2022 01.

Article en En | MEDLINE | ID: mdl-34826736

Asunto(s)

Reparación del ADN; Desoxirribonucleasa (Dímero de Pirimidina)/metabolismo; Fibroblastos/enzimología; Inestabilidad Genómica; Mutación Missense; Animales; ADN/efectos de los fármacos; ADN/metabolismo; Daño del ADN; Desoxirribonucleasa (Dímero de Pirimidina)/genética; Fibroblastos/metabolismo; Técnicas de Sustitución del Gen; Ratones; Ratones Mutantes; Mutágenos/toxicidad; Estrés Oxidativo; Vitamina K 3/toxicidad

Palabras clave

Base excision repair; Genomic instability; NTHL1 glycosylase; Oxidative DNA damage

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Mutación Missense / Inestabilidad Genómica / Desoxirribonucleasa (Dímero de Pirimidina) / Reparación del ADN / Fibroblastos Límite: Animals Idioma: En Revista: DNA Repair (Amst) Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2022 Tipo del documento: Article

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